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Update on the Role of FeNO in Asthma Management
Asthma is a heterogenous disorder characterized by presence of different phenotypes and endotypes. Up to 10% of the individuals suffer from severe asthma and are at increased risk of morbidity and mortality. Fractional exhaled nitric oxide (FeNO) is a cost-effective, point of care biomarker that is...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137365/ https://www.ncbi.nlm.nih.gov/pubmed/37189529 http://dx.doi.org/10.3390/diagnostics13081428 |
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author | Murugesan, Neveda Saxena, Damini Dileep, Arundhati Adrish, Muhammad Hanania, Nicola A. |
author_facet | Murugesan, Neveda Saxena, Damini Dileep, Arundhati Adrish, Muhammad Hanania, Nicola A. |
author_sort | Murugesan, Neveda |
collection | PubMed |
description | Asthma is a heterogenous disorder characterized by presence of different phenotypes and endotypes. Up to 10% of the individuals suffer from severe asthma and are at increased risk of morbidity and mortality. Fractional exhaled nitric oxide (FeNO) is a cost-effective, point of care biomarker that is used to detect type 2 airway inflammation. Guidelines have proposed to measure FeNO as an adjunct to diagnostic evaluation in individuals with suspected asthma and to monitor airway inflammation. FeNO has lower sensitivity, suggesting that it may not be a good biomarker to rule out asthma. FeNO may also be used to predict response to inhaled corticosteroids, predict adherence and deciding on biologic therapy. Higher levels of FeNO have been associated with lower lung function and increased risk for future asthma exacerbations and its predictive value increases when combined with other standard measurements of asthma assessment. |
format | Online Article Text |
id | pubmed-10137365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101373652023-04-28 Update on the Role of FeNO in Asthma Management Murugesan, Neveda Saxena, Damini Dileep, Arundhati Adrish, Muhammad Hanania, Nicola A. Diagnostics (Basel) Review Asthma is a heterogenous disorder characterized by presence of different phenotypes and endotypes. Up to 10% of the individuals suffer from severe asthma and are at increased risk of morbidity and mortality. Fractional exhaled nitric oxide (FeNO) is a cost-effective, point of care biomarker that is used to detect type 2 airway inflammation. Guidelines have proposed to measure FeNO as an adjunct to diagnostic evaluation in individuals with suspected asthma and to monitor airway inflammation. FeNO has lower sensitivity, suggesting that it may not be a good biomarker to rule out asthma. FeNO may also be used to predict response to inhaled corticosteroids, predict adherence and deciding on biologic therapy. Higher levels of FeNO have been associated with lower lung function and increased risk for future asthma exacerbations and its predictive value increases when combined with other standard measurements of asthma assessment. MDPI 2023-04-15 /pmc/articles/PMC10137365/ /pubmed/37189529 http://dx.doi.org/10.3390/diagnostics13081428 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Murugesan, Neveda Saxena, Damini Dileep, Arundhati Adrish, Muhammad Hanania, Nicola A. Update on the Role of FeNO in Asthma Management |
title | Update on the Role of FeNO in Asthma Management |
title_full | Update on the Role of FeNO in Asthma Management |
title_fullStr | Update on the Role of FeNO in Asthma Management |
title_full_unstemmed | Update on the Role of FeNO in Asthma Management |
title_short | Update on the Role of FeNO in Asthma Management |
title_sort | update on the role of feno in asthma management |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137365/ https://www.ncbi.nlm.nih.gov/pubmed/37189529 http://dx.doi.org/10.3390/diagnostics13081428 |
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