Cargando…
Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demo...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137398/ https://www.ncbi.nlm.nih.gov/pubmed/37185440 http://dx.doi.org/10.3390/curroncol30040327 |
_version_ | 1785032453725880320 |
---|---|
author | Đokanović, Dejan Gajanin, Radoslav Gojković, Zdenka Marošević, Goran Sladojević, Igor Gajanin, Vesna Jović-Đokanović, Olja Amidžić, Ljiljana |
author_facet | Đokanović, Dejan Gajanin, Radoslav Gojković, Zdenka Marošević, Goran Sladojević, Igor Gajanin, Vesna Jović-Đokanović, Olja Amidžić, Ljiljana |
author_sort | Đokanović, Dejan |
collection | PubMed |
description | Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival. |
format | Online Article Text |
id | pubmed-10137398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101373982023-04-28 Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer Đokanović, Dejan Gajanin, Radoslav Gojković, Zdenka Marošević, Goran Sladojević, Igor Gajanin, Vesna Jović-Đokanović, Olja Amidžić, Ljiljana Curr Oncol Article Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival. MDPI 2023-04-20 /pmc/articles/PMC10137398/ /pubmed/37185440 http://dx.doi.org/10.3390/curroncol30040327 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Đokanović, Dejan Gajanin, Radoslav Gojković, Zdenka Marošević, Goran Sladojević, Igor Gajanin, Vesna Jović-Đokanović, Olja Amidžić, Ljiljana Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title | Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title_full | Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title_fullStr | Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title_full_unstemmed | Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title_short | Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer |
title_sort | clinicopathological characteristics, treatment patterns, and outcomes in patients with laryngeal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137398/ https://www.ncbi.nlm.nih.gov/pubmed/37185440 http://dx.doi.org/10.3390/curroncol30040327 |
work_keys_str_mv | AT đokanovicdejan clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT gajaninradoslav clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT gojkoviczdenka clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT marosevicgoran clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT sladojevicigor clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT gajaninvesna clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT jovicđokanovicolja clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer AT amidzicljiljana clinicopathologicalcharacteristicstreatmentpatternsandoutcomesinpatientswithlaryngealcancer |