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Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer

Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demo...

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Autores principales: Đokanović, Dejan, Gajanin, Radoslav, Gojković, Zdenka, Marošević, Goran, Sladojević, Igor, Gajanin, Vesna, Jović-Đokanović, Olja, Amidžić, Ljiljana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137398/
https://www.ncbi.nlm.nih.gov/pubmed/37185440
http://dx.doi.org/10.3390/curroncol30040327
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author Đokanović, Dejan
Gajanin, Radoslav
Gojković, Zdenka
Marošević, Goran
Sladojević, Igor
Gajanin, Vesna
Jović-Đokanović, Olja
Amidžić, Ljiljana
author_facet Đokanović, Dejan
Gajanin, Radoslav
Gojković, Zdenka
Marošević, Goran
Sladojević, Igor
Gajanin, Vesna
Jović-Đokanović, Olja
Amidžić, Ljiljana
author_sort Đokanović, Dejan
collection PubMed
description Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival.
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spelling pubmed-101373982023-04-28 Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer Đokanović, Dejan Gajanin, Radoslav Gojković, Zdenka Marošević, Goran Sladojević, Igor Gajanin, Vesna Jović-Đokanović, Olja Amidžić, Ljiljana Curr Oncol Article Background: Various factors can affect the survival of patients with laryngeal cancer (LC). In this retrospective study, we assessed clinicopathological features, their prognostic value, and treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median NR. After conducting a multivariate analysis of significant variables, we found that only recurrence and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted patient survival. MDPI 2023-04-20 /pmc/articles/PMC10137398/ /pubmed/37185440 http://dx.doi.org/10.3390/curroncol30040327 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Đokanović, Dejan
Gajanin, Radoslav
Gojković, Zdenka
Marošević, Goran
Sladojević, Igor
Gajanin, Vesna
Jović-Đokanović, Olja
Amidžić, Ljiljana
Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title_full Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title_fullStr Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title_full_unstemmed Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title_short Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer
title_sort clinicopathological characteristics, treatment patterns, and outcomes in patients with laryngeal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137398/
https://www.ncbi.nlm.nih.gov/pubmed/37185440
http://dx.doi.org/10.3390/curroncol30040327
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