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Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study

Background: This pilot study examined the relationship between the Coma Recovery Scale-Revised (CRS-R) and the five subparts of the thalamocortical tract in chronic patients with hypoxic–ischemic brain injury by diffusion tensor tractography (DTT). Methods: Seventeen consecutive chronic patients wit...

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Autores principales: Jang, Sungho, Choi, Eunbi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137777/
https://www.ncbi.nlm.nih.gov/pubmed/37107982
http://dx.doi.org/10.3390/healthcare11081148
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author Jang, Sungho
Choi, Eunbi
author_facet Jang, Sungho
Choi, Eunbi
author_sort Jang, Sungho
collection PubMed
description Background: This pilot study examined the relationship between the Coma Recovery Scale-Revised (CRS-R) and the five subparts of the thalamocortical tract in chronic patients with hypoxic–ischemic brain injury by diffusion tensor tractography (DTT). Methods: Seventeen consecutive chronic patients with hypoxic–ischemic brain injury were recruited. The consciousness state was evaluated using CRS-R. The five subparts of the thalamocortical tract (the prefrontal cortex, the premotor cortex, the primary motor cortex, the primary somatosensory cortex, and the posterior parietal cortex) were reconstructed using DTT. Fractional anisotropy and the tract volume of each subpart of the thalamocortical tract were estimated. Results: The CRS-R score showed a moderate positive correlation with the tract volume of the prefrontal cortex part of the thalamocortical tract (p < 0.05). In addition, the tract volume of the prefrontal cortex component of the thalamocortical tract could explain the variability in the CRS-R score (p < 0.05). Conclusion: The prefrontal cortex part was closely related to the CRS-R score in chronic patients with hypoxic–ischemic brain injury. In addition, the change in the remaining number of neural fibers of the prefrontal cortex part appeared to be related to the change in conscious state.
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spelling pubmed-101377772023-04-28 Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study Jang, Sungho Choi, Eunbi Healthcare (Basel) Article Background: This pilot study examined the relationship between the Coma Recovery Scale-Revised (CRS-R) and the five subparts of the thalamocortical tract in chronic patients with hypoxic–ischemic brain injury by diffusion tensor tractography (DTT). Methods: Seventeen consecutive chronic patients with hypoxic–ischemic brain injury were recruited. The consciousness state was evaluated using CRS-R. The five subparts of the thalamocortical tract (the prefrontal cortex, the premotor cortex, the primary motor cortex, the primary somatosensory cortex, and the posterior parietal cortex) were reconstructed using DTT. Fractional anisotropy and the tract volume of each subpart of the thalamocortical tract were estimated. Results: The CRS-R score showed a moderate positive correlation with the tract volume of the prefrontal cortex part of the thalamocortical tract (p < 0.05). In addition, the tract volume of the prefrontal cortex component of the thalamocortical tract could explain the variability in the CRS-R score (p < 0.05). Conclusion: The prefrontal cortex part was closely related to the CRS-R score in chronic patients with hypoxic–ischemic brain injury. In addition, the change in the remaining number of neural fibers of the prefrontal cortex part appeared to be related to the change in conscious state. MDPI 2023-04-17 /pmc/articles/PMC10137777/ /pubmed/37107982 http://dx.doi.org/10.3390/healthcare11081148 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jang, Sungho
Choi, Eunbi
Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title_full Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title_fullStr Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title_full_unstemmed Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title_short Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
title_sort relationship between coma recovery scale-revised and the thalamocortical tract of ascending reticular activating system in hypoxic–ischemic brain injury: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137777/
https://www.ncbi.nlm.nih.gov/pubmed/37107982
http://dx.doi.org/10.3390/healthcare11081148
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