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A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence

The rate of alcoholic hepatitis (AH) has risen in recent years. AH can cause as much as 40–50% mortality in severe cases. Successful abstinence has been the only therapy associated with long-term survival in patients with AH. Thus, it is crucial to be able to identify at-risk individuals in order to...

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Autores principales: Tun, Kyaw Min, Dossaji, Zahra, Massey, Blaine L., Batra, Kavita, Lo, Chun-Han, Naga, Yassin, Mohammed, Salman, Muraga, Abebe, Gill, Ahmad, Mukhopadhyay, Dwaipayan, Singh, Ashok, Lankarani, Daisy, Aponte-Pieras, Jose, Ohning, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138017/
https://www.ncbi.nlm.nih.gov/pubmed/37107538
http://dx.doi.org/10.3390/genes14040780
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author Tun, Kyaw Min
Dossaji, Zahra
Massey, Blaine L.
Batra, Kavita
Lo, Chun-Han
Naga, Yassin
Mohammed, Salman
Muraga, Abebe
Gill, Ahmad
Mukhopadhyay, Dwaipayan
Singh, Ashok
Lankarani, Daisy
Aponte-Pieras, Jose
Ohning, Gordon
author_facet Tun, Kyaw Min
Dossaji, Zahra
Massey, Blaine L.
Batra, Kavita
Lo, Chun-Han
Naga, Yassin
Mohammed, Salman
Muraga, Abebe
Gill, Ahmad
Mukhopadhyay, Dwaipayan
Singh, Ashok
Lankarani, Daisy
Aponte-Pieras, Jose
Ohning, Gordon
author_sort Tun, Kyaw Min
collection PubMed
description The rate of alcoholic hepatitis (AH) has risen in recent years. AH can cause as much as 40–50% mortality in severe cases. Successful abstinence has been the only therapy associated with long-term survival in patients with AH. Thus, it is crucial to be able to identify at-risk individuals in order to implement preventative measures. From the patient database, adult patients (age 18 and above) with AH were identified using the ICD-10 classification from November 2017 to October 2019. Liver biopsies are not routinely performed at our institution. Therefore, patients were diagnosed with AH based on clinical parameters and were divided into “probable” and “possible” AH. Logistic regression analysis was performed to determine risk factors associated with AH. A sub-analysis was performed to determine variables associated with mortality in AH patients. Among the 192 patients with alcohol dependence, there were 100 patients with AH and 92 patients without AH. The mean age was 49.3 years in the AH cohort, compared to 54.5 years in the non-AH cohort. Binge drinking (OR 2.698; 95% CI 1.079, 6.745; p = 0.03), heavy drinking (OR 3.169; 95% CI 1.348, 7.452; p = 0.01), and the presence of cirrhosis (OR 3.392; 95% CI 1.306, 8.811; p = 0.01) were identified as characteristics more commonly found in the AH cohort. Further, a higher inpatient mortality was seen in those with a probable AH diagnosis (OR 6.79; 95% CI 1.38, 44.9; p = 0.03) and hypertension (OR 6.51; 95% CI 9.49, 35.7; p = 0.02). A higher incidence of mortality was also noted among the non-Caucasian race (OR 2.72; 95% CI 4.92; 22.3; p = 0.29). A higher mortality rate despite a lower incidence of alcohol use among non-Caucasian patients may indicate healthcare disparities.
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spelling pubmed-101380172023-04-28 A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence Tun, Kyaw Min Dossaji, Zahra Massey, Blaine L. Batra, Kavita Lo, Chun-Han Naga, Yassin Mohammed, Salman Muraga, Abebe Gill, Ahmad Mukhopadhyay, Dwaipayan Singh, Ashok Lankarani, Daisy Aponte-Pieras, Jose Ohning, Gordon Genes (Basel) Project Report The rate of alcoholic hepatitis (AH) has risen in recent years. AH can cause as much as 40–50% mortality in severe cases. Successful abstinence has been the only therapy associated with long-term survival in patients with AH. Thus, it is crucial to be able to identify at-risk individuals in order to implement preventative measures. From the patient database, adult patients (age 18 and above) with AH were identified using the ICD-10 classification from November 2017 to October 2019. Liver biopsies are not routinely performed at our institution. Therefore, patients were diagnosed with AH based on clinical parameters and were divided into “probable” and “possible” AH. Logistic regression analysis was performed to determine risk factors associated with AH. A sub-analysis was performed to determine variables associated with mortality in AH patients. Among the 192 patients with alcohol dependence, there were 100 patients with AH and 92 patients without AH. The mean age was 49.3 years in the AH cohort, compared to 54.5 years in the non-AH cohort. Binge drinking (OR 2.698; 95% CI 1.079, 6.745; p = 0.03), heavy drinking (OR 3.169; 95% CI 1.348, 7.452; p = 0.01), and the presence of cirrhosis (OR 3.392; 95% CI 1.306, 8.811; p = 0.01) were identified as characteristics more commonly found in the AH cohort. Further, a higher inpatient mortality was seen in those with a probable AH diagnosis (OR 6.79; 95% CI 1.38, 44.9; p = 0.03) and hypertension (OR 6.51; 95% CI 9.49, 35.7; p = 0.02). A higher incidence of mortality was also noted among the non-Caucasian race (OR 2.72; 95% CI 4.92; 22.3; p = 0.29). A higher mortality rate despite a lower incidence of alcohol use among non-Caucasian patients may indicate healthcare disparities. MDPI 2023-03-23 /pmc/articles/PMC10138017/ /pubmed/37107538 http://dx.doi.org/10.3390/genes14040780 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Project Report
Tun, Kyaw Min
Dossaji, Zahra
Massey, Blaine L.
Batra, Kavita
Lo, Chun-Han
Naga, Yassin
Mohammed, Salman
Muraga, Abebe
Gill, Ahmad
Mukhopadhyay, Dwaipayan
Singh, Ashok
Lankarani, Daisy
Aponte-Pieras, Jose
Ohning, Gordon
A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title_full A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title_fullStr A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title_full_unstemmed A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title_short A Comparative Study of Acute Alcoholic Hepatitis vs. Non-Alcoholic Hepatitis Patients from a Cohort with Chronic Alcohol Dependence
title_sort comparative study of acute alcoholic hepatitis vs. non-alcoholic hepatitis patients from a cohort with chronic alcohol dependence
topic Project Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138017/
https://www.ncbi.nlm.nih.gov/pubmed/37107538
http://dx.doi.org/10.3390/genes14040780
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