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Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity
PURPOSE: Platelets have a major role in the regulation of angiogenesis. Platelets have proangiogenic factors like vascular endothelial growth factor, which causes neovascularization of immature retina. However, there is no conclusive evidence to show that platelet indices have a role in retinopathy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138134/ https://www.ncbi.nlm.nih.gov/pubmed/37123426 http://dx.doi.org/10.4103/meajo.meajo_246_21 |
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author | Reddy, Rudhira M. Bhandary, Sulatha V. Rao, Krishna A. Lewis, Leslie E. Lal, Shivakumar M. Rachel, Namitha M. |
author_facet | Reddy, Rudhira M. Bhandary, Sulatha V. Rao, Krishna A. Lewis, Leslie E. Lal, Shivakumar M. Rachel, Namitha M. |
author_sort | Reddy, Rudhira M. |
collection | PubMed |
description | PURPOSE: Platelets have a major role in the regulation of angiogenesis. Platelets have proangiogenic factors like vascular endothelial growth factor, which causes neovascularization of immature retina. However, there is no conclusive evidence to show that platelet indices have a role in retinopathy of prematurity (ROP). This study is aimed at assessing the role of platelet indices in the occurrence and need for treatment of ROP. METHODS: This prospective cohort study included the screening of preterm babies (<37 weeks of gestation with birth weight <2000 g). The samples of platelet indices (mean platelet volume [MPV], platelet count [PLT], plateletcrit [PCT], and platelet distribution width [PDW]) collected within 1(st) week of life were obtained from the electronic medical records and correlated to ROP status. Statistical analysis was done using SPSS version 22, and the Chi-square test and odds ratio were used for analysis. RESULTS: A total of 300 preterm babies were screened, of whom, 55 (18.3%) babies had ROP changes. The association of the presence of ROP changes and platelet indices was not statistically significant (P value being MPV [0.22], PLT [0.58], PCT [0.98], and PDW [0.17]). Similarly, the requirement of treatment for ROP (Type I ROP) could not be correlated with abnormal platelet indices (odds ratio at 95% confidence interval – MPV [6 (0.44–81.44)], PLT [1.7 (0.25–11.37)], PCT [3 (0.44–20.90)], and PDW [0.32 (0.33–3.05)]). CONCLUSION: Abnormal platelet indices did not show any significant risk with the occurrence or need for treatment of ROP. |
format | Online Article Text |
id | pubmed-10138134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101381342023-04-28 Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity Reddy, Rudhira M. Bhandary, Sulatha V. Rao, Krishna A. Lewis, Leslie E. Lal, Shivakumar M. Rachel, Namitha M. Middle East Afr J Ophthalmol Original Article PURPOSE: Platelets have a major role in the regulation of angiogenesis. Platelets have proangiogenic factors like vascular endothelial growth factor, which causes neovascularization of immature retina. However, there is no conclusive evidence to show that platelet indices have a role in retinopathy of prematurity (ROP). This study is aimed at assessing the role of platelet indices in the occurrence and need for treatment of ROP. METHODS: This prospective cohort study included the screening of preterm babies (<37 weeks of gestation with birth weight <2000 g). The samples of platelet indices (mean platelet volume [MPV], platelet count [PLT], plateletcrit [PCT], and platelet distribution width [PDW]) collected within 1(st) week of life were obtained from the electronic medical records and correlated to ROP status. Statistical analysis was done using SPSS version 22, and the Chi-square test and odds ratio were used for analysis. RESULTS: A total of 300 preterm babies were screened, of whom, 55 (18.3%) babies had ROP changes. The association of the presence of ROP changes and platelet indices was not statistically significant (P value being MPV [0.22], PLT [0.58], PCT [0.98], and PDW [0.17]). Similarly, the requirement of treatment for ROP (Type I ROP) could not be correlated with abnormal platelet indices (odds ratio at 95% confidence interval – MPV [6 (0.44–81.44)], PLT [1.7 (0.25–11.37)], PCT [3 (0.44–20.90)], and PDW [0.32 (0.33–3.05)]). CONCLUSION: Abnormal platelet indices did not show any significant risk with the occurrence or need for treatment of ROP. Wolters Kluwer - Medknow 2023-02-24 /pmc/articles/PMC10138134/ /pubmed/37123426 http://dx.doi.org/10.4103/meajo.meajo_246_21 Text en Copyright: © 2023 Middle East African Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Reddy, Rudhira M. Bhandary, Sulatha V. Rao, Krishna A. Lewis, Leslie E. Lal, Shivakumar M. Rachel, Namitha M. Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title | Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title_full | Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title_fullStr | Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title_full_unstemmed | Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title_short | Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity |
title_sort | assessment of role of platelet indices in the occurrence of retinopathy of prematurity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138134/ https://www.ncbi.nlm.nih.gov/pubmed/37123426 http://dx.doi.org/10.4103/meajo.meajo_246_21 |
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