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Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels

Polymer gels are usually used for crystal growth as the recovered crystals have better properties. Fast crystallization under nanoscale confinement holds great benefits, especially in polymer microgels as its tunable microstructures. This study demonstrated that ethyl vanillin can be quickly crystal...

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Autores principales: Huang, Chenghong, Tang, Hong, Huang, Xiaorong, Chen, Hongjie, Yang, Kang, Yin, Qi, Zhang, Lin, Li, Xia, Mou, Xue, Chen, Shuangkou, Zhang, Yuchan, Hu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138138/
https://www.ncbi.nlm.nih.gov/pubmed/37102947
http://dx.doi.org/10.3390/gels9040335
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author Huang, Chenghong
Tang, Hong
Huang, Xiaorong
Chen, Hongjie
Yang, Kang
Yin, Qi
Zhang, Lin
Li, Xia
Mou, Xue
Chen, Shuangkou
Zhang, Yuchan
Hu, Yan
author_facet Huang, Chenghong
Tang, Hong
Huang, Xiaorong
Chen, Hongjie
Yang, Kang
Yin, Qi
Zhang, Lin
Li, Xia
Mou, Xue
Chen, Shuangkou
Zhang, Yuchan
Hu, Yan
author_sort Huang, Chenghong
collection PubMed
description Polymer gels are usually used for crystal growth as the recovered crystals have better properties. Fast crystallization under nanoscale confinement holds great benefits, especially in polymer microgels as its tunable microstructures. This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. It found that EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration less than 1:0.8. It was observed that EVA crystal growth has two models involving hang-wall growth at the air-liquid interface at the contact line, as well as extrude-bubble growth at any sites on the liquid surface. Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs.
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spelling pubmed-101381382023-04-28 Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels Huang, Chenghong Tang, Hong Huang, Xiaorong Chen, Hongjie Yang, Kang Yin, Qi Zhang, Lin Li, Xia Mou, Xue Chen, Shuangkou Zhang, Yuchan Hu, Yan Gels Article Polymer gels are usually used for crystal growth as the recovered crystals have better properties. Fast crystallization under nanoscale confinement holds great benefits, especially in polymer microgels as its tunable microstructures. This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. It found that EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration less than 1:0.8. It was observed that EVA crystal growth has two models involving hang-wall growth at the air-liquid interface at the contact line, as well as extrude-bubble growth at any sites on the liquid surface. Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs. MDPI 2023-04-14 /pmc/articles/PMC10138138/ /pubmed/37102947 http://dx.doi.org/10.3390/gels9040335 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Chenghong
Tang, Hong
Huang, Xiaorong
Chen, Hongjie
Yang, Kang
Yin, Qi
Zhang, Lin
Li, Xia
Mou, Xue
Chen, Shuangkou
Zhang, Yuchan
Hu, Yan
Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title_full Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title_fullStr Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title_full_unstemmed Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title_short Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels
title_sort ethyl vanillin rapid crystallization from carboxymethyl chitosan ion-switchable hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138138/
https://www.ncbi.nlm.nih.gov/pubmed/37102947
http://dx.doi.org/10.3390/gels9040335
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