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Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138162/ https://www.ncbi.nlm.nih.gov/pubmed/37102945 http://dx.doi.org/10.3390/gels9040333 |
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author | Yooyod, Maytinee Ross, Sukunya Phewchan, Premchirakorn Daengmankhong, Jinjutha Pinthong, Thanyaporn Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Ross, Gareth M. |
author_facet | Yooyod, Maytinee Ross, Sukunya Phewchan, Premchirakorn Daengmankhong, Jinjutha Pinthong, Thanyaporn Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Ross, Gareth M. |
author_sort | Yooyod, Maytinee |
collection | PubMed |
description | This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi’s model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels. |
format | Online Article Text |
id | pubmed-10138162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101381622023-04-28 Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release Yooyod, Maytinee Ross, Sukunya Phewchan, Premchirakorn Daengmankhong, Jinjutha Pinthong, Thanyaporn Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Ross, Gareth M. Gels Article This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi’s model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels. MDPI 2023-04-14 /pmc/articles/PMC10138162/ /pubmed/37102945 http://dx.doi.org/10.3390/gels9040333 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yooyod, Maytinee Ross, Sukunya Phewchan, Premchirakorn Daengmankhong, Jinjutha Pinthong, Thanyaporn Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Ross, Gareth M. Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title | Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title_full | Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title_fullStr | Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title_full_unstemmed | Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title_short | Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release |
title_sort | homo- and copolymer hydrogels based on n-vinylformamide: an investigation of the impact of water structure on controlled release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138162/ https://www.ncbi.nlm.nih.gov/pubmed/37102945 http://dx.doi.org/10.3390/gels9040333 |
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