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Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release

This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The...

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Detalles Bibliográficos
Autores principales: Yooyod, Maytinee, Ross, Sukunya, Phewchan, Premchirakorn, Daengmankhong, Jinjutha, Pinthong, Thanyaporn, Tuancharoensri, Nantaprapa, Mahasaranon, Sararat, Viyoch, Jarupa, Ross, Gareth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138162/
https://www.ncbi.nlm.nih.gov/pubmed/37102945
http://dx.doi.org/10.3390/gels9040333
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author Yooyod, Maytinee
Ross, Sukunya
Phewchan, Premchirakorn
Daengmankhong, Jinjutha
Pinthong, Thanyaporn
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Ross, Gareth M.
author_facet Yooyod, Maytinee
Ross, Sukunya
Phewchan, Premchirakorn
Daengmankhong, Jinjutha
Pinthong, Thanyaporn
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Ross, Gareth M.
author_sort Yooyod, Maytinee
collection PubMed
description This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi’s model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels.
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spelling pubmed-101381622023-04-28 Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release Yooyod, Maytinee Ross, Sukunya Phewchan, Premchirakorn Daengmankhong, Jinjutha Pinthong, Thanyaporn Tuancharoensri, Nantaprapa Mahasaranon, Sararat Viyoch, Jarupa Ross, Gareth M. Gels Article This study investigated the performance of novel hydrogels based on poly (N-vinylformamide) (PNVF), copolymers of NVF with N-hydroxyethyl acrylamide (HEA) (P(NVF-co-HEA)), and 2-carboxyethyl acrylate (CEA) (P(NVF-co-CEA)), which were synthesized by photopolymerization using a UVLED light source. The hydrogels were analyzed for important properties such as equilibrium water content (%EWC), contact angle, freezing and non-freezing water, and diffusion-based in vitro release. The results showed that PNVF had an extremely high %EWC of 94.57%, while a decreasing NVF content in the copolymer hydrogels led to a decrease in water content with a linear relationship with HEA or CEA content. Water structuring in the hydrogels showed appreciably more variance, with ratios of free to bound water differing from 16.7:1 (NVF) to 1.3:1 (CEA), corresponding to PNVF having ~67 water molecules per repeat unit. The release studies of different dye molecules followed Higuchi’s model, with the amount of dye released from the hydrogels depending on the amount of free water and the structural interactions between the polymer and the molecule being released. The results suggest that PNVF copolymer hydrogels have potential for controlled drug delivery by altering the polymer composition to govern the amount and ratio of free to bound water contained in the hydrogels. MDPI 2023-04-14 /pmc/articles/PMC10138162/ /pubmed/37102945 http://dx.doi.org/10.3390/gels9040333 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yooyod, Maytinee
Ross, Sukunya
Phewchan, Premchirakorn
Daengmankhong, Jinjutha
Pinthong, Thanyaporn
Tuancharoensri, Nantaprapa
Mahasaranon, Sararat
Viyoch, Jarupa
Ross, Gareth M.
Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title_full Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title_fullStr Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title_full_unstemmed Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title_short Homo- and Copolymer Hydrogels Based on N-Vinylformamide: An Investigation of the Impact of Water Structure on Controlled Release
title_sort homo- and copolymer hydrogels based on n-vinylformamide: an investigation of the impact of water structure on controlled release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138162/
https://www.ncbi.nlm.nih.gov/pubmed/37102945
http://dx.doi.org/10.3390/gels9040333
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