In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study

A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent (18)FDG PET/CT and (68)Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology (18)FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological u...

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Detalles Bibliográficos
Autores principales: Wang, Jingnan, Huo, Li, Lin, Lu, Niu, Na, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138181/
https://www.ncbi.nlm.nih.gov/pubmed/37189551
http://dx.doi.org/10.3390/diagnostics13081450
Descripción
Sumario:A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent (18)FDG PET/CT and (68)Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology (18)FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological uptake. The following (68)Ga-FAPI-04 showed intense heterogeneous uptake in the left ventricular wall, particularly in the septum and apex area, corresponding with the late gadolinium enhancement regions shown by cardiac MR. Intense uptake was also noted in the mediastinal and bilateral hilar lymph nodes. Endomyocardial biopsy demonstrated sarcoidosis.

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