In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study

A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent (18)FDG PET/CT and (68)Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology (18)FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological u...

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Autores principales: Wang, Jingnan, Huo, Li, Lin, Lu, Niu, Na, Li, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138181/
https://www.ncbi.nlm.nih.gov/pubmed/37189551
http://dx.doi.org/10.3390/diagnostics13081450
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author Wang, Jingnan
Huo, Li
Lin, Lu
Niu, Na
Li, Xiang
author_facet Wang, Jingnan
Huo, Li
Lin, Lu
Niu, Na
Li, Xiang
author_sort Wang, Jingnan
collection PubMed
description A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent (18)FDG PET/CT and (68)Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology (18)FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological uptake. The following (68)Ga-FAPI-04 showed intense heterogeneous uptake in the left ventricular wall, particularly in the septum and apex area, corresponding with the late gadolinium enhancement regions shown by cardiac MR. Intense uptake was also noted in the mediastinal and bilateral hilar lymph nodes. Endomyocardial biopsy demonstrated sarcoidosis.
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spelling pubmed-101381812023-04-28 In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study Wang, Jingnan Huo, Li Lin, Lu Niu, Na Li, Xiang Diagnostics (Basel) Interesting Images A 47-year-old female with cardiac dysfunction and lymphadenopathy underwent (18)FDG PET/CT and (68)Ga-FAPI-04 imaging for tumor screening. Mild uptake in the left ventricular wall was detected on the oncology (18)FDG PET/CT. True myocardiac-involvement could not be distinguished with physiological uptake. The following (68)Ga-FAPI-04 showed intense heterogeneous uptake in the left ventricular wall, particularly in the septum and apex area, corresponding with the late gadolinium enhancement regions shown by cardiac MR. Intense uptake was also noted in the mediastinal and bilateral hilar lymph nodes. Endomyocardial biopsy demonstrated sarcoidosis. MDPI 2023-04-17 /pmc/articles/PMC10138181/ /pubmed/37189551 http://dx.doi.org/10.3390/diagnostics13081450 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Interesting Images
Wang, Jingnan
Huo, Li
Lin, Lu
Niu, Na
Li, Xiang
In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title_full In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title_fullStr In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title_full_unstemmed In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title_short In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
title_sort in vivo fibroblast activation of systemic sarcoidosis: a (68)ga-fapi-04 pet/ct imaging study
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138181/
https://www.ncbi.nlm.nih.gov/pubmed/37189551
http://dx.doi.org/10.3390/diagnostics13081450
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