Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones

Prader-Willi syndrome (PWS) is a multisystem disorder with neurobehavioral, metabolic, and hormonal phenotypes, caused by loss of expression of a paternally-expressed imprinted gene cluster. Prior evidence from a PWS mouse model identified abnormal pancreatic islet development with retention of aged...

Descripción completa

Detalles Bibliográficos
Autores principales: Koppes, Erik A., Johnson, Marie A., Moresco, James J., Luppi, Patrizia, Lewis, Dale W., Stolz, Donna B., Diedrich, Jolene K., Yates, John R., Wek, Ronald C., Watkins, Simon C., Gollin, Susanne M., Park, Hyun Jung, Drain, Peter, Nicholls, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138222/
https://www.ncbi.nlm.nih.gov/pubmed/37068109
http://dx.doi.org/10.1371/journal.pgen.1010710

Ejemplares similares

Ejemplares similares