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Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery

Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes—chitosan and pectin—were used, du...

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Autores principales: Vildanova, Regina R., Petrova, Svetlana F., Kolesov, Sergey V., Khutoryanskiy, Vitaliy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138284/
https://www.ncbi.nlm.nih.gov/pubmed/37102954
http://dx.doi.org/10.3390/gels9040342
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author Vildanova, Regina R.
Petrova, Svetlana F.
Kolesov, Sergey V.
Khutoryanskiy, Vitaliy V.
author_facet Vildanova, Regina R.
Petrova, Svetlana F.
Kolesov, Sergey V.
Khutoryanskiy, Vitaliy V.
author_sort Vildanova, Regina R.
collection PubMed
description Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes—chitosan and pectin—were used, due to their biocompatibility and biodegradability. The biodegradability of hydrogels is confirmed by experiments with hyaluronidase as an enzyme. It has been shown that the use of pectins with different molecular weights makes it possible to prepare hydrogels with different rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels loaded with cytostatic cisplatin as a model drug provide an opportunity for its prolonged release, which is important for therapy. The drug release is regulated to a certain extent by the choice of hydrogel composition. The developed systems can potentially improve the effects of cancer treatment due to the prolonged release of cytostatic cisplatin.
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spelling pubmed-101382842023-04-28 Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery Vildanova, Regina R. Petrova, Svetlana F. Kolesov, Sergey V. Khutoryanskiy, Vitaliy V. Gels Article Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes—chitosan and pectin—were used, due to their biocompatibility and biodegradability. The biodegradability of hydrogels is confirmed by experiments with hyaluronidase as an enzyme. It has been shown that the use of pectins with different molecular weights makes it possible to prepare hydrogels with different rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels loaded with cytostatic cisplatin as a model drug provide an opportunity for its prolonged release, which is important for therapy. The drug release is regulated to a certain extent by the choice of hydrogel composition. The developed systems can potentially improve the effects of cancer treatment due to the prolonged release of cytostatic cisplatin. MDPI 2023-04-17 /pmc/articles/PMC10138284/ /pubmed/37102954 http://dx.doi.org/10.3390/gels9040342 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vildanova, Regina R.
Petrova, Svetlana F.
Kolesov, Sergey V.
Khutoryanskiy, Vitaliy V.
Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title_full Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title_fullStr Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title_full_unstemmed Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title_short Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery
title_sort biodegradable hydrogels based on chitosan and pectin for cisplatin delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138284/
https://www.ncbi.nlm.nih.gov/pubmed/37102954
http://dx.doi.org/10.3390/gels9040342
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