Cargando…

Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders

Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder caused by loss-of-function mutations in the tumour suppressors TSC1/TSC2, both of which are negative regulators of the mammalian target of rapamycin (mTOR) kinase. Importantly, mTOR hyperactivity seems to be linked with the path...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gąssowska-Dobrowolska, Magdalena, Czapski, Grzegorz A., Cieślik, Magdalena, Zajdel, Karolina, Frontczak-Baniewicz, Małgorzata, Babiec, Lidia, Adamczyk, Agata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138344/ https://www.ncbi.nlm.nih.gov/pubmed/37108467 http://dx.doi.org/10.3390/ijms24087303

Ejemplares similares

Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2020)

The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation
por: Cieślik, Magdalena, et al.
Publicado: (2021)

Alterations in Cerebellar Microtubule Cytoskeletal Network in a ValproicAcid-Induced Rat Model of Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2022)

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells
por: Gąssowska, Magdalena, et al.
Publicado: (2014)

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells
por: Wilkaniec, Anna, et al.
Publicado: (2020)

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring
por: Cieślik, Magdalena, et al.
Publicado: (2020)

P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
por: Wilkaniec, Anna, et al.
Publicado: (2017)

Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
por: Wilkaniec, Anna, et al.
Publicado: (2018)

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders
por: Babiec, Lidia, et al.
Publicado: (2023)

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology
por: Wilkaniec, Anna, et al.
Publicado: (2018)

Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2021)

Developmental Stage-Dependent Changes in Mitochondrial Function in the Brain of Offspring Following Prenatal Maternal Immune Activation
por: Cieślik, Magdalena, et al.
Publicado: (2023)

Upconverting Nanoparticles as a New Bio-Imaging Strategy—Investigating Intracellular Trafficking of Endogenous Processes in Neural Tissue
por: Zajdel, Karolina, et al.
Publicado: (2023)

Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology
por: Wilkaniec, Anna, et al.
Publicado: (2021)

The Role of Maternal Immune Activation in the Pathogenesis of Autism: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment
por: Zawadzka, Aleksandra, et al.
Publicado: (2021)

The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer’s Disease
por: Matuszewska, Marta, et al.
Publicado: (2022)

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
por: Cieślik, Magdalena, et al.
Publicado: (2015)

A Low Dose of Nanoparticulate Silver Induces Mitochondrial Dysfunction and Autophagy in Adult Rat Brain
por: Skalska, Joanna, et al.
Publicado: (2020)

Early and Delayed Impact of Nanosilver on the Glutamatergic NMDA Receptor Complex in Immature Rat Brain
por: Dąbrowska-Bouta, Beata, et al.
Publicado: (2021)

Cortical synapses in acute hepatic encephalopathy: morphology and expression of proteins involved in synaptic transmission
por: Popek, Mariusz, et al.
Publicado: (2015)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

On the Significance of Microtubule Flexural Behavior in Cytoskeletal Mechanics
por: Mehrbod, Mehrdad, et al.
Publicado: (2011)

Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications
por: Kowalik, Przemyslaw, et al.
Publicado: (2020)

AUTISM IN TUBEROUS SCLEROSIS
por: Khanna, Rakesh, et al.
Publicado: (1991)

Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events
por: Popek, Mariusz, et al.
Publicado: (2017)

Ultrastructural Changes in Mitochondria in Patients with Dilated Cardiomyopathy and Parvovirus B19 Detected in Heart Tissue without Myocarditis
por: Pawlak, Agnieszka, et al.
Publicado: (2022)

Multiple forms of tubulin in the cytoskeletal and flagellar microtubules of polytomella
por: McKeithan, TW, et al.
Publicado: (1981)

Defects of microtubule cytoskeletal organization in NOA human testes
por: Wu, Xiaolong, et al.
Publicado: (2022)

Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer’s Disease
por: Cieślik, Magdalena, et al.
Publicado: (2019)

Tuberous Sclerosis Complex in Autism
por: Guo, Xin, et al.
Publicado: (2012)

Vascularization Potential of Electrospun Poly(L-Lactide-co-Caprolactone) Scaffold: The Impact for Tissue Engineering
por: Jundziłł, Arkadiusz, et al.
Publicado: (2017)

Perineuronal Nets and Their Role in Synaptic Homeostasis
por: Bosiacki, Mateusz, et al.
Publicado: (2019)

Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau
por: Brandt, Roland, et al.
Publicado: (2020)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
por: Jęśko, Henryk, et al.
Publicado: (2021)

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms
por: Korbecki, Jan, et al.
Publicado: (2021)

The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System
por: Korbecki, Jan, et al.
Publicado: (2022)

Ectromelia virus induces tubulin cytoskeletal rearrangement in immune cells accompanied by a loss of the microtubule organizing center and increased α-tubulin acetylation
por: Szulc-Dąbrowska, Lidia, et al.
Publicado: (2018)

Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation?
por: Craddock, Travis J. A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1tu8rkjqd4jqtujlbl3kj5e5vn