Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery

Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. Platelets are among the first cells recruited to sites of inflammation and infection and they exert...

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Autores principales: Trivigno, Silvia M. G., Guidetti, Gianni Francesco, Barbieri, Silvia Stella, Zarà, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138547/
https://www.ncbi.nlm.nih.gov/pubmed/37108623
http://dx.doi.org/10.3390/ijms24087462
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author Trivigno, Silvia M. G.
Guidetti, Gianni Francesco
Barbieri, Silvia Stella
Zarà, Marta
author_facet Trivigno, Silvia M. G.
Guidetti, Gianni Francesco
Barbieri, Silvia Stella
Zarà, Marta
author_sort Trivigno, Silvia M. G.
collection PubMed
description Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. Platelets are among the first cells recruited to sites of inflammation and infection and they exert their antimicrobial response actively cooperating with the immune system. This review aims to summarize the current knowledge on platelet receptor interaction with different types of pathogens and the consequent modulations of innate and adaptive immune responses.
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spelling pubmed-101385472023-04-28 Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery Trivigno, Silvia M. G. Guidetti, Gianni Francesco Barbieri, Silvia Stella Zarà, Marta Int J Mol Sci Review Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. Platelets are among the first cells recruited to sites of inflammation and infection and they exert their antimicrobial response actively cooperating with the immune system. This review aims to summarize the current knowledge on platelet receptor interaction with different types of pathogens and the consequent modulations of innate and adaptive immune responses. MDPI 2023-04-18 /pmc/articles/PMC10138547/ /pubmed/37108623 http://dx.doi.org/10.3390/ijms24087462 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trivigno, Silvia M. G.
Guidetti, Gianni Francesco
Barbieri, Silvia Stella
Zarà, Marta
Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title_full Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title_fullStr Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title_full_unstemmed Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title_short Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
title_sort blood platelets in infection: the multiple roles of the platelet signalling machinery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138547/
https://www.ncbi.nlm.nih.gov/pubmed/37108623
http://dx.doi.org/10.3390/ijms24087462
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