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Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma

During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of it...

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Autores principales: Santos, Benedito M. Dos, Przyborski, Jude M., Garcia, Célia R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138558/
https://www.ncbi.nlm.nih.gov/pubmed/37108438
http://dx.doi.org/10.3390/ijms24087276
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author Santos, Benedito M. Dos
Przyborski, Jude M.
Garcia, Célia R. S.
author_facet Santos, Benedito M. Dos
Przyborski, Jude M.
Garcia, Célia R. S.
author_sort Santos, Benedito M. Dos
collection PubMed
description During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in cytosolic calcium. In the present report, we summarize the information available in the literature regarding the role of potassium ions during parasite development. A deeper understanding of the mechanisms that allow the parasite to cope with ionic potassium changes contributes to our knowledge about the cell cycle of Plasmodium spp.
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spelling pubmed-101385582023-04-28 Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma Santos, Benedito M. Dos Przyborski, Jude M. Garcia, Célia R. S. Int J Mol Sci Review During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in cytosolic calcium. In the present report, we summarize the information available in the literature regarding the role of potassium ions during parasite development. A deeper understanding of the mechanisms that allow the parasite to cope with ionic potassium changes contributes to our knowledge about the cell cycle of Plasmodium spp. MDPI 2023-04-14 /pmc/articles/PMC10138558/ /pubmed/37108438 http://dx.doi.org/10.3390/ijms24087276 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santos, Benedito M. Dos
Przyborski, Jude M.
Garcia, Célia R. S.
Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title_full Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title_fullStr Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title_full_unstemmed Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title_short Changes in K(+) Concentration as a Signaling Mechanism in the Apicomplexa Parasites Plasmodium and Toxoplasma
title_sort changes in k(+) concentration as a signaling mechanism in the apicomplexa parasites plasmodium and toxoplasma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138558/
https://www.ncbi.nlm.nih.gov/pubmed/37108438
http://dx.doi.org/10.3390/ijms24087276
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