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Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process
Lipid droplets (LDs) are ubiquitous, dynamic organelles found in almost all organisms, including animals, protists, plants and prokaryotes. The cell biology of LDs, especially biogenesis, has attracted increasing attention in recent decades because of their important role in cellular lipid metabolis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138601/ https://www.ncbi.nlm.nih.gov/pubmed/37108639 http://dx.doi.org/10.3390/ijms24087476 |
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author | Zhao, Yiwu Dong, Qingdi Geng, Yuhu Ma, Changle Shao, Qun |
author_facet | Zhao, Yiwu Dong, Qingdi Geng, Yuhu Ma, Changle Shao, Qun |
author_sort | Zhao, Yiwu |
collection | PubMed |
description | Lipid droplets (LDs) are ubiquitous, dynamic organelles found in almost all organisms, including animals, protists, plants and prokaryotes. The cell biology of LDs, especially biogenesis, has attracted increasing attention in recent decades because of their important role in cellular lipid metabolism and other newly identified processes. Emerging evidence suggests that LD biogenesis is a highly coordinated and stepwise process in animals and yeasts, occurring at specific sites of the endoplasmic reticulum (ER) that are defined by both evolutionarily conserved and organism- and cell type-specific LD lipids and proteins. In plants, understanding of the mechanistic details of LD formation is elusive as many questions remain. In some ways LD biogenesis differs between plants and animals. Several homologous proteins involved in the regulation of animal LD formation in plants have been identified. We try to describe how these proteins are synthesized, transported to the ER and specifically targeted to LD, and how these proteins participate in the regulation of LD biogenesis. Here, we review current work on the molecular processes that control LD formation in plant cells and highlight the proteins that govern this process, hoping to provide useful clues for future research. |
format | Online Article Text |
id | pubmed-10138601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101386012023-04-28 Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process Zhao, Yiwu Dong, Qingdi Geng, Yuhu Ma, Changle Shao, Qun Int J Mol Sci Review Lipid droplets (LDs) are ubiquitous, dynamic organelles found in almost all organisms, including animals, protists, plants and prokaryotes. The cell biology of LDs, especially biogenesis, has attracted increasing attention in recent decades because of their important role in cellular lipid metabolism and other newly identified processes. Emerging evidence suggests that LD biogenesis is a highly coordinated and stepwise process in animals and yeasts, occurring at specific sites of the endoplasmic reticulum (ER) that are defined by both evolutionarily conserved and organism- and cell type-specific LD lipids and proteins. In plants, understanding of the mechanistic details of LD formation is elusive as many questions remain. In some ways LD biogenesis differs between plants and animals. Several homologous proteins involved in the regulation of animal LD formation in plants have been identified. We try to describe how these proteins are synthesized, transported to the ER and specifically targeted to LD, and how these proteins participate in the regulation of LD biogenesis. Here, we review current work on the molecular processes that control LD formation in plant cells and highlight the proteins that govern this process, hoping to provide useful clues for future research. MDPI 2023-04-19 /pmc/articles/PMC10138601/ /pubmed/37108639 http://dx.doi.org/10.3390/ijms24087476 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhao, Yiwu Dong, Qingdi Geng, Yuhu Ma, Changle Shao, Qun Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title | Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title_full | Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title_fullStr | Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title_full_unstemmed | Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title_short | Dynamic Regulation of Lipid Droplet Biogenesis in Plant Cells and Proteins Involved in the Process |
title_sort | dynamic regulation of lipid droplet biogenesis in plant cells and proteins involved in the process |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138601/ https://www.ncbi.nlm.nih.gov/pubmed/37108639 http://dx.doi.org/10.3390/ijms24087476 |
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