Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans

The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N...

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Detalles Bibliográficos
Autores principales: Di Giorgi, Alessandro, Sprega, Giorgia, Poyatos, Lourdes, Papaseit, Esther, Pérez-Mañá, Clara, Di Trana, Annagiulia, Varì, Maria Rosaria, Busardò, Francesco Paolo, Pichini, Simona, Zaami, Simona, Lo Faro, Alfredo Fabrizio, Farré, Magí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138602/
https://www.ncbi.nlm.nih.gov/pubmed/37108557
http://dx.doi.org/10.3390/ijms24087395
Descripción
Sumario:The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC) were analyzed in sweat patches by liquid chromatography–tandem mass spectrometry. Methylone and MDC were detected in sweat at 2 h and reached their highest accumulation (C(max)) at 24 h after the administration of 50, 100, 150 and 200 mg doses. In contrast, HMMC was not detectable at any time interval after each dose. Sweat proved to be a suitable matrix for methylone and its metabolites’ determination in clinical and toxicological studies, providing a concentration that reveals recent drug consumption.

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