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Advances in the Electrophysiological Recordings of Long-Term Potentiation

Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring...

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Autores principales: Jiang, Feixu, Bello, Stephen Temitayo, Gao, Qianqian, Lai, Yuanying, Li, Xiao, He, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138642/
https://www.ncbi.nlm.nih.gov/pubmed/37108295
http://dx.doi.org/10.3390/ijms24087134
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author Jiang, Feixu
Bello, Stephen Temitayo
Gao, Qianqian
Lai, Yuanying
Li, Xiao
He, Ling
author_facet Jiang, Feixu
Bello, Stephen Temitayo
Gao, Qianqian
Lai, Yuanying
Li, Xiao
He, Ling
author_sort Jiang, Feixu
collection PubMed
description Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring the mechanisms and pathways involved in LTP induction, and detection ability of neuronal action potentiation signals. This review will reiterate LTP-related electrophysiological recordings in the mammalian brain for nearly 50 years and explain how excitatory and inhibitory neural LTP results have been detected and described by field- and single-cell potentials, respectively. Furthermore, we focus on describing the classic model of LTP of inhibition and discuss the inhibitory neuron activity when excitatory neurons are activated to induce LTP. Finally, we propose recording excitatory and inhibitory neurons under the same experimental conditions by combining various electrophysiological technologies and novel design suggestions for future research. We discussed different types of synaptic plasticity, and the potential of astrocytes to induce LTP also deserves to be explored in the future.
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spelling pubmed-101386422023-04-28 Advances in the Electrophysiological Recordings of Long-Term Potentiation Jiang, Feixu Bello, Stephen Temitayo Gao, Qianqian Lai, Yuanying Li, Xiao He, Ling Int J Mol Sci Review Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring the mechanisms and pathways involved in LTP induction, and detection ability of neuronal action potentiation signals. This review will reiterate LTP-related electrophysiological recordings in the mammalian brain for nearly 50 years and explain how excitatory and inhibitory neural LTP results have been detected and described by field- and single-cell potentials, respectively. Furthermore, we focus on describing the classic model of LTP of inhibition and discuss the inhibitory neuron activity when excitatory neurons are activated to induce LTP. Finally, we propose recording excitatory and inhibitory neurons under the same experimental conditions by combining various electrophysiological technologies and novel design suggestions for future research. We discussed different types of synaptic plasticity, and the potential of astrocytes to induce LTP also deserves to be explored in the future. MDPI 2023-04-12 /pmc/articles/PMC10138642/ /pubmed/37108295 http://dx.doi.org/10.3390/ijms24087134 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Feixu
Bello, Stephen Temitayo
Gao, Qianqian
Lai, Yuanying
Li, Xiao
He, Ling
Advances in the Electrophysiological Recordings of Long-Term Potentiation
title Advances in the Electrophysiological Recordings of Long-Term Potentiation
title_full Advances in the Electrophysiological Recordings of Long-Term Potentiation
title_fullStr Advances in the Electrophysiological Recordings of Long-Term Potentiation
title_full_unstemmed Advances in the Electrophysiological Recordings of Long-Term Potentiation
title_short Advances in the Electrophysiological Recordings of Long-Term Potentiation
title_sort advances in the electrophysiological recordings of long-term potentiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138642/
https://www.ncbi.nlm.nih.gov/pubmed/37108295
http://dx.doi.org/10.3390/ijms24087134
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