Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking

The selectivity of drugs for G protein-coupled receptor (GPCR) signaling pathways is crucial for their therapeutic efficacy. Different agonists can cause receptors to recruit effector proteins at varying levels, thus inducing different signaling responses, called signaling bias. Although several GPC...

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Detalles Bibliográficos
Autores principales: Wang, Dongxue, Yao, Yunjin, Wang, Shiqi, Hou, Yifei, Zhao, Lanxue, Wang, Hao, Chen, Hongzhuan, Xu, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138654/
https://www.ncbi.nlm.nih.gov/pubmed/37108518
http://dx.doi.org/10.3390/ijms24087356

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