Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study

Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups called warheads. Covalent inhibition has an advantage in terms of pharmacodynamic pro...

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Detalles Bibliográficos
Autores principales: Müller, Patrick, Meta, Mergim, Meidner, Jan Laurenz, Schwickert, Marvin, Meyr, Jessica, Schwickert, Kevin, Kersten, Christian, Zimmer, Collin, Hammerschmidt, Stefan Josef, Frey, Ariane, Lahu, Albin, de la Hoz-Rodríguez, Sergio, Agost-Beltrán, Laura, Rodríguez, Santiago, Diemer, Kira, Neumann, Wilhelm, Gonzàlez, Florenci V., Engels, Bernd, Schirmeister, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138721/
https://www.ncbi.nlm.nih.gov/pubmed/37108388
http://dx.doi.org/10.3390/ijms24087226

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