LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib

Gastrointestinal stromal tumor (GIST), the most common sarcoma, is mainly caused by an oncogenic mutation in the KIT receptor tyrosine kinase. Targeting KIT using tyrosine kinase inhibitors, such as imatinib and sunitinib, provides substantial benefit; however, in most patients, the disease will eve...

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Detalles Bibliográficos
Autores principales: Ruiz-Demoulin, Salomé, Trenquier, Eva, Dekkar, Sanaa, Deshayes, Sébastien, Boisguérin, Prisca, Serrano, César, de Santa Barbara, Pascal, Faure, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138740/
https://www.ncbi.nlm.nih.gov/pubmed/37108337
http://dx.doi.org/10.3390/ijms24087138

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