Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing

Genetically modified CHO cell lines are traditionally used for the production of biopharmaceuticals. However, an in‐depth molecular understanding of the mechanism and exact position of transgene integration into the genome of pharmaceutical manufacturing cell lines is still scarce. Next‐generation s...

Descripción completa

Detalles Bibliográficos
Autores principales: Stadermann, Anna, Gamer, Martin, Fieder, Jürgen, Lindner, Benjamin, Fehrmann, Steffen, Schmidt, Moritz, Schulz, Patrick, Gorr, Ingo H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138747/
https://www.ncbi.nlm.nih.gov/pubmed/34935125
http://dx.doi.org/10.1002/bit.28012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138747/
https://www.ncbi.nlm.nih.gov/pubmed/34935125
http://dx.doi.org/10.1002/bit.28012

Ejemplares similares