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Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing

Genetically modified CHO cell lines are traditionally used for the production of biopharmaceuticals. However, an in‐depth molecular understanding of the mechanism and exact position of transgene integration into the genome of pharmaceutical manufacturing cell lines is still scarce. Next‐generation s...

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Detalles Bibliográficos
Autores principales:	Stadermann, Anna, Gamer, Martin, Fieder, Jürgen, Lindner, Benjamin, Fehrmann, Steffen, Schmidt, Moritz, Schulz, Patrick, Gorr, Ingo H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138747/ https://www.ncbi.nlm.nih.gov/pubmed/34935125 http://dx.doi.org/10.1002/bit.28012

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