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Characterization of a convection‐based support microstructure through a flow resistance parameter
Modern convection‐based supports differ substantially in pore size, porosity, and microstructure topology. Due to such variability, it is challenging to evaluate the contribution of a particular microstructure topology on flow resistance. We demonstrated that the flow resistance parameter ([Formula:...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138761/ https://www.ncbi.nlm.nih.gov/pubmed/35218615 http://dx.doi.org/10.1002/jssc.202100955 |
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author | Podgornik, Aleš |
author_facet | Podgornik, Aleš |
author_sort | Podgornik, Aleš |
collection | PubMed |
description | Modern convection‐based supports differ substantially in pore size, porosity, and microstructure topology. Due to such variability, it is challenging to evaluate the contribution of a particular microstructure topology on flow resistance. We demonstrated that the flow resistance parameter ([Formula: see text]) introduced decades ago can be used as a criterion to evaluate the effect of microstructure topology on a pressure drop when the pore size is used as a characteristic support dimension. Furthermore, the [Formula: see text] value of simple cubic packing was calculated over the entire range of open porosity and compared to the [Formula: see text] values determined for pressure drop models derived for particular convection‐based supports and experimental values of various convection‐based supports from the literature. It was shown that different convection‐based supports become clustered into distinct groups when plotted according to their [Formula: see text] and open porosity values, allowing their discrimination. |
format | Online Article Text |
id | pubmed-10138761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101387612023-04-28 Characterization of a convection‐based support microstructure through a flow resistance parameter Podgornik, Aleš J Sep Sci Liquid Chromatography Modern convection‐based supports differ substantially in pore size, porosity, and microstructure topology. Due to such variability, it is challenging to evaluate the contribution of a particular microstructure topology on flow resistance. We demonstrated that the flow resistance parameter ([Formula: see text]) introduced decades ago can be used as a criterion to evaluate the effect of microstructure topology on a pressure drop when the pore size is used as a characteristic support dimension. Furthermore, the [Formula: see text] value of simple cubic packing was calculated over the entire range of open porosity and compared to the [Formula: see text] values determined for pressure drop models derived for particular convection‐based supports and experimental values of various convection‐based supports from the literature. It was shown that different convection‐based supports become clustered into distinct groups when plotted according to their [Formula: see text] and open porosity values, allowing their discrimination. John Wiley and Sons Inc. 2022-03-07 2022-06 /pmc/articles/PMC10138761/ /pubmed/35218615 http://dx.doi.org/10.1002/jssc.202100955 Text en © 2022 The Authors. Journal of Separation Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Liquid Chromatography Podgornik, Aleš Characterization of a convection‐based support microstructure through a flow resistance parameter |
title | Characterization of a convection‐based support microstructure through a flow resistance parameter |
title_full | Characterization of a convection‐based support microstructure through a flow resistance parameter |
title_fullStr | Characterization of a convection‐based support microstructure through a flow resistance parameter |
title_full_unstemmed | Characterization of a convection‐based support microstructure through a flow resistance parameter |
title_short | Characterization of a convection‐based support microstructure through a flow resistance parameter |
title_sort | characterization of a convection‐based support microstructure through a flow resistance parameter |
topic | Liquid Chromatography |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138761/ https://www.ncbi.nlm.nih.gov/pubmed/35218615 http://dx.doi.org/10.1002/jssc.202100955 |
work_keys_str_mv | AT podgornikales characterizationofaconvectionbasedsupportmicrostructurethroughaflowresistanceparameter |