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Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT(1)R/G(αq)-Mediated TGF-β1 and ET-1 Signaling

Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the signal transduction of angiotensin II receptor (ATR) for upregulation of TGF-β1 and ET-1, and their effectors th...

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Detalles Bibliográficos
Autores principales:	Duangrat, Ratchanee, Parichatikanond, Warisara, Mangmool, Supachoke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138810/ https://www.ncbi.nlm.nih.gov/pubmed/37108136 http://dx.doi.org/10.3390/ijms24086972

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