Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function

Implantable Cardiovascular Therapeutic Devices (CTD), while lifesaving, impart supraphysiologic shear stress to platelets, resulting in thrombotic and bleeding coagulopathy. We previously demonstrated that shear-mediated platelet dysfunction is associated with downregulation of platelet GPIb-IX-V an...

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Detalles Bibliográficos
Autores principales: Roka-Moiia, Yana, Ammann, Kaitlyn R., Miller-Gutierrez, Samuel, Sheriff, Jawaad, Bluestein, Danny, Italiano, Joseph E., Flaumenhaft, Robert C., Slepian, Marvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138836/
https://www.ncbi.nlm.nih.gov/pubmed/37108551
http://dx.doi.org/10.3390/ijms24087386

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