Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation

Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, suc...

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Autores principales: Wang, Desheng, Gomes, Marta T., Mo, Yanfei, Prohaska, Clare C., Zhang, Lu, Chelvanambi, Sarvesh, Clauss, Matthias A., Zhang, Dongfang, Machado, Roberto F., Gao, Mingqi, Bai, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138839/
https://www.ncbi.nlm.nih.gov/pubmed/37108634
http://dx.doi.org/10.3390/ijms24087472
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author Wang, Desheng
Gomes, Marta T.
Mo, Yanfei
Prohaska, Clare C.
Zhang, Lu
Chelvanambi, Sarvesh
Clauss, Matthias A.
Zhang, Dongfang
Machado, Roberto F.
Gao, Mingqi
Bai, Yang
author_facet Wang, Desheng
Gomes, Marta T.
Mo, Yanfei
Prohaska, Clare C.
Zhang, Lu
Chelvanambi, Sarvesh
Clauss, Matthias A.
Zhang, Dongfang
Machado, Roberto F.
Gao, Mingqi
Bai, Yang
author_sort Wang, Desheng
collection PubMed
description Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.
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spelling pubmed-101388392023-04-28 Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation Wang, Desheng Gomes, Marta T. Mo, Yanfei Prohaska, Clare C. Zhang, Lu Chelvanambi, Sarvesh Clauss, Matthias A. Zhang, Dongfang Machado, Roberto F. Gao, Mingqi Bai, Yang Int J Mol Sci Review Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease. MDPI 2023-04-18 /pmc/articles/PMC10138839/ /pubmed/37108634 http://dx.doi.org/10.3390/ijms24087472 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Desheng
Gomes, Marta T.
Mo, Yanfei
Prohaska, Clare C.
Zhang, Lu
Chelvanambi, Sarvesh
Clauss, Matthias A.
Zhang, Dongfang
Machado, Roberto F.
Gao, Mingqi
Bai, Yang
Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title_full Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title_fullStr Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title_full_unstemmed Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title_short Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
title_sort human endogenous retrovirus, sars-cov-2, and hiv promote pah via inflammation and growth stimulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138839/
https://www.ncbi.nlm.nih.gov/pubmed/37108634
http://dx.doi.org/10.3390/ijms24087472
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