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Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome

A significant fraction of couples around the world suffer from polycystic ovarian syndrome (PCOS), a disease defined by the characteristics of enhanced androgen synthesis in ovarian theca cells, hyperandrogenemia, and ovarian dysfunction in women. Most of the clinically observable symptoms and alter...

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Autores principales: Khan, Muhammad Sohaib, Kim, Hee-Sun, Kim, Ranhee, Yoon, Sang Ho, Kim, Sang Geon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138914/
https://www.ncbi.nlm.nih.gov/pubmed/37108615
http://dx.doi.org/10.3390/ijms24087454
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author Khan, Muhammad Sohaib
Kim, Hee-Sun
Kim, Ranhee
Yoon, Sang Ho
Kim, Sang Geon
author_facet Khan, Muhammad Sohaib
Kim, Hee-Sun
Kim, Ranhee
Yoon, Sang Ho
Kim, Sang Geon
author_sort Khan, Muhammad Sohaib
collection PubMed
description A significant fraction of couples around the world suffer from polycystic ovarian syndrome (PCOS), a disease defined by the characteristics of enhanced androgen synthesis in ovarian theca cells, hyperandrogenemia, and ovarian dysfunction in women. Most of the clinically observable symptoms and altered blood biomarker levels in the patients indicate metabolic dysregulation and adaptive changes as the key underlying mechanisms. Since the liver is the metabolic hub of the body and is involved in steroid-hormonal detoxification, pathological changes in the liver may contribute to female endocrine disruption, potentially through the liver-to-ovary axis. Of particular interest are hyperglycemic challenges and the consequent changes in liver-secretory protein(s) and insulin sensitivity affecting the maturation of ovarian follicles, potentially leading to female infertility. The purpose of this review is to provide insight into emerging metabolic mechanisms underlying PCOS as the primary culprit, which promote its incidence and aggravation. Additionally, this review aims to summarize medications and new potential therapeutic approaches for the disease.
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spelling pubmed-101389142023-04-28 Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome Khan, Muhammad Sohaib Kim, Hee-Sun Kim, Ranhee Yoon, Sang Ho Kim, Sang Geon Int J Mol Sci Review A significant fraction of couples around the world suffer from polycystic ovarian syndrome (PCOS), a disease defined by the characteristics of enhanced androgen synthesis in ovarian theca cells, hyperandrogenemia, and ovarian dysfunction in women. Most of the clinically observable symptoms and altered blood biomarker levels in the patients indicate metabolic dysregulation and adaptive changes as the key underlying mechanisms. Since the liver is the metabolic hub of the body and is involved in steroid-hormonal detoxification, pathological changes in the liver may contribute to female endocrine disruption, potentially through the liver-to-ovary axis. Of particular interest are hyperglycemic challenges and the consequent changes in liver-secretory protein(s) and insulin sensitivity affecting the maturation of ovarian follicles, potentially leading to female infertility. The purpose of this review is to provide insight into emerging metabolic mechanisms underlying PCOS as the primary culprit, which promote its incidence and aggravation. Additionally, this review aims to summarize medications and new potential therapeutic approaches for the disease. MDPI 2023-04-18 /pmc/articles/PMC10138914/ /pubmed/37108615 http://dx.doi.org/10.3390/ijms24087454 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Muhammad Sohaib
Kim, Hee-Sun
Kim, Ranhee
Yoon, Sang Ho
Kim, Sang Geon
Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title_full Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title_fullStr Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title_full_unstemmed Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title_short Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
title_sort dysregulated liver metabolism and polycystic ovarian syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138914/
https://www.ncbi.nlm.nih.gov/pubmed/37108615
http://dx.doi.org/10.3390/ijms24087454
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