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The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat

Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversi...

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Autores principales: Hammad, Fayez T., Lubbad, Loay, Al-Salam, Suhail, Yasin, Javed, Meeran, Mohamed Fizur Nagoor, Ojha, Shreesh, Hammad, Waheed F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138964/
https://www.ncbi.nlm.nih.gov/pubmed/37108528
http://dx.doi.org/10.3390/ijms24087365
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author Hammad, Fayez T.
Lubbad, Loay
Al-Salam, Suhail
Yasin, Javed
Meeran, Mohamed Fizur Nagoor
Ojha, Shreesh
Hammad, Waheed F.
author_facet Hammad, Fayez T.
Lubbad, Loay
Al-Salam, Suhail
Yasin, Javed
Meeran, Mohamed Fizur Nagoor
Ojha, Shreesh
Hammad, Waheed F.
author_sort Hammad, Fayez T.
collection PubMed
description Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversible UO has not been studied previously. To study this effect, spontaneously hypertensive (G-HT, n = 10) and normotensive Wistar (G-NT, n = 10) rats underwent 48-h reversible left unilateral UO (UUO), and the effect of UUO was studied 96 h following UUO reversal. The glomerular filtration rate, renal blood flow, and renal tubular functions such as the fractional excretion of sodium in the post-obstructed left kidney (POK) in both groups were significantly altered compared with the non-obstructed right kidney (NOK). However, the alterations in the G-HT were significantly more exaggerated when compared with the G-NT. Similar findings were observed with the histological features, gene expression of kidney injury markers, pro-inflammatory, pro-fibrotic and pro-apoptotic cytokines, and pro-collagen, as well as tissue levels of apoptotic markers. We conclude that hypertension has significantly exaggerated the alterations in renal functions and other parameters of renal injury associated with UUO.
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spelling pubmed-101389642023-04-28 The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat Hammad, Fayez T. Lubbad, Loay Al-Salam, Suhail Yasin, Javed Meeran, Mohamed Fizur Nagoor Ojha, Shreesh Hammad, Waheed F. Int J Mol Sci Article Both ureteral obstruction (UO) and hypertension are common conditions that affect kidney functions. Hypertension and chronic kidney disease are closely associated with an overlapping and intermingled cause-and-effect relationship. The effect of hypertension on the renal dysfunction following reversible UO has not been studied previously. To study this effect, spontaneously hypertensive (G-HT, n = 10) and normotensive Wistar (G-NT, n = 10) rats underwent 48-h reversible left unilateral UO (UUO), and the effect of UUO was studied 96 h following UUO reversal. The glomerular filtration rate, renal blood flow, and renal tubular functions such as the fractional excretion of sodium in the post-obstructed left kidney (POK) in both groups were significantly altered compared with the non-obstructed right kidney (NOK). However, the alterations in the G-HT were significantly more exaggerated when compared with the G-NT. Similar findings were observed with the histological features, gene expression of kidney injury markers, pro-inflammatory, pro-fibrotic and pro-apoptotic cytokines, and pro-collagen, as well as tissue levels of apoptotic markers. We conclude that hypertension has significantly exaggerated the alterations in renal functions and other parameters of renal injury associated with UUO. MDPI 2023-04-17 /pmc/articles/PMC10138964/ /pubmed/37108528 http://dx.doi.org/10.3390/ijms24087365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hammad, Fayez T.
Lubbad, Loay
Al-Salam, Suhail
Yasin, Javed
Meeran, Mohamed Fizur Nagoor
Ojha, Shreesh
Hammad, Waheed F.
The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title_full The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title_fullStr The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title_full_unstemmed The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title_short The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
title_sort effect of hypertension on the recovery of renal dysfunction following reversal of unilateral ureteral obstruction in the rat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138964/
https://www.ncbi.nlm.nih.gov/pubmed/37108528
http://dx.doi.org/10.3390/ijms24087365
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