Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway

Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with KRAS-mutant driven cancers. In this review, we focus on recent s...

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Detalles Bibliográficos
Autores principales: Harwood, Stephen J., Smith, Christopher R., Lawson, J. David, Ketcham, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139024/
https://www.ncbi.nlm.nih.gov/pubmed/37108538
http://dx.doi.org/10.3390/ijms24087373
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author Harwood, Stephen J.
Smith, Christopher R.
Lawson, J. David
Ketcham, John M.
author_facet Harwood, Stephen J.
Smith, Christopher R.
Lawson, J. David
Ketcham, John M.
author_sort Harwood, Stephen J.
collection PubMed
description Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with KRAS-mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.
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spelling pubmed-101390242023-04-28 Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway Harwood, Stephen J. Smith, Christopher R. Lawson, J. David Ketcham, John M. Int J Mol Sci Review Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with KRAS-mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS. MDPI 2023-04-17 /pmc/articles/PMC10139024/ /pubmed/37108538 http://dx.doi.org/10.3390/ijms24087373 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harwood, Stephen J.
Smith, Christopher R.
Lawson, J. David
Ketcham, John M.
Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title_full Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title_fullStr Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title_full_unstemmed Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title_short Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
title_sort selected approaches to disrupting protein–protein interactions within the mapk/ras pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139024/
https://www.ncbi.nlm.nih.gov/pubmed/37108538
http://dx.doi.org/10.3390/ijms24087373
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