Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges

Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carrier...

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Detalles Bibliográficos
Autores principales: Oshchepkova, Anastasiya, Zenkova, Marina, Vlassov, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139028/
https://www.ncbi.nlm.nih.gov/pubmed/37108446
http://dx.doi.org/10.3390/ijms24087287
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author Oshchepkova, Anastasiya
Zenkova, Marina
Vlassov, Valentin
author_facet Oshchepkova, Anastasiya
Zenkova, Marina
Vlassov, Valentin
author_sort Oshchepkova, Anastasiya
collection PubMed
description Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carriers, creating new opportunities for drug delivery. In this review, we discuss the ability of EVs to function as carriers for therapeutic nucleic acids (tNAs), challenges associated with the use of such carriers in vivo, and various strategies for tNA loading into EVs.
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spelling pubmed-101390282023-04-28 Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges Oshchepkova, Anastasiya Zenkova, Marina Vlassov, Valentin Int J Mol Sci Review Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by cells of various origins. They contain different biological cargoes, protecting them from degradation by environmental factors. There is an opinion that EVs have a number of advantages over synthetic carriers, creating new opportunities for drug delivery. In this review, we discuss the ability of EVs to function as carriers for therapeutic nucleic acids (tNAs), challenges associated with the use of such carriers in vivo, and various strategies for tNA loading into EVs. MDPI 2023-04-14 /pmc/articles/PMC10139028/ /pubmed/37108446 http://dx.doi.org/10.3390/ijms24087287 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oshchepkova, Anastasiya
Zenkova, Marina
Vlassov, Valentin
Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title_full Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title_fullStr Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title_full_unstemmed Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title_short Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
title_sort extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139028/
https://www.ncbi.nlm.nih.gov/pubmed/37108446
http://dx.doi.org/10.3390/ijms24087287
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AT vlassovvalentin extracellularvesiclesfortherapeuticnucleicaciddeliveryloadingstrategiesandchallenges

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