Cargando…

The Influence of Polyphenols on Atherosclerosis Development

Polyphenols have attracted tremendous attention due to their pro-health properties, including their antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis is th...

Descripción completa

Detalles Bibliográficos
Autores principales: Ziółkiewicz, Agnieszka, Kasprzak-Drozd, Kamila, Rusinek, Robert, Markut-Miotła, Ewa, Oniszczuk, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139042/
https://www.ncbi.nlm.nih.gov/pubmed/37108307
http://dx.doi.org/10.3390/ijms24087146
_version_ 1785032850688442368
author Ziółkiewicz, Agnieszka
Kasprzak-Drozd, Kamila
Rusinek, Robert
Markut-Miotła, Ewa
Oniszczuk, Anna
author_facet Ziółkiewicz, Agnieszka
Kasprzak-Drozd, Kamila
Rusinek, Robert
Markut-Miotła, Ewa
Oniszczuk, Anna
author_sort Ziółkiewicz, Agnieszka
collection PubMed
description Polyphenols have attracted tremendous attention due to their pro-health properties, including their antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis is the type and quality of food consumed. Therefore, polyphenols represent promising agents in the prevention and treatment of atherosclerosis, as demonstrated by in vitro, animal, preclinical and clinical studies. However, most polyphenols cannot be absorbed directly by the small intestine. Gut microbiota play a crucial role in converting dietary polyphenols into absorbable bioactive substances. An increasing understanding of the field has confirmed that specific GM taxa strains mediate the gut microbiota–atherosclerosis axis. The present study explores the anti-atherosclerotic properties and associated underlying mechanisms of polyphenols. Moreover, it provides a basis for better understanding the relationship between dietary polyphenols, gut microbiota, and cardiovascular benefits.
format Online
Article
Text
id pubmed-10139042
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101390422023-04-28 The Influence of Polyphenols on Atherosclerosis Development Ziółkiewicz, Agnieszka Kasprzak-Drozd, Kamila Rusinek, Robert Markut-Miotła, Ewa Oniszczuk, Anna Int J Mol Sci Review Polyphenols have attracted tremendous attention due to their pro-health properties, including their antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis is the type and quality of food consumed. Therefore, polyphenols represent promising agents in the prevention and treatment of atherosclerosis, as demonstrated by in vitro, animal, preclinical and clinical studies. However, most polyphenols cannot be absorbed directly by the small intestine. Gut microbiota play a crucial role in converting dietary polyphenols into absorbable bioactive substances. An increasing understanding of the field has confirmed that specific GM taxa strains mediate the gut microbiota–atherosclerosis axis. The present study explores the anti-atherosclerotic properties and associated underlying mechanisms of polyphenols. Moreover, it provides a basis for better understanding the relationship between dietary polyphenols, gut microbiota, and cardiovascular benefits. MDPI 2023-04-12 /pmc/articles/PMC10139042/ /pubmed/37108307 http://dx.doi.org/10.3390/ijms24087146 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ziółkiewicz, Agnieszka
Kasprzak-Drozd, Kamila
Rusinek, Robert
Markut-Miotła, Ewa
Oniszczuk, Anna
The Influence of Polyphenols on Atherosclerosis Development
title The Influence of Polyphenols on Atherosclerosis Development
title_full The Influence of Polyphenols on Atherosclerosis Development
title_fullStr The Influence of Polyphenols on Atherosclerosis Development
title_full_unstemmed The Influence of Polyphenols on Atherosclerosis Development
title_short The Influence of Polyphenols on Atherosclerosis Development
title_sort influence of polyphenols on atherosclerosis development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139042/
https://www.ncbi.nlm.nih.gov/pubmed/37108307
http://dx.doi.org/10.3390/ijms24087146
work_keys_str_mv AT ziołkiewiczagnieszka theinfluenceofpolyphenolsonatherosclerosisdevelopment
AT kasprzakdrozdkamila theinfluenceofpolyphenolsonatherosclerosisdevelopment
AT rusinekrobert theinfluenceofpolyphenolsonatherosclerosisdevelopment
AT markutmiotłaewa theinfluenceofpolyphenolsonatherosclerosisdevelopment
AT oniszczukanna theinfluenceofpolyphenolsonatherosclerosisdevelopment
AT ziołkiewiczagnieszka influenceofpolyphenolsonatherosclerosisdevelopment
AT kasprzakdrozdkamila influenceofpolyphenolsonatherosclerosisdevelopment
AT rusinekrobert influenceofpolyphenolsonatherosclerosisdevelopment
AT markutmiotłaewa influenceofpolyphenolsonatherosclerosisdevelopment
AT oniszczukanna influenceofpolyphenolsonatherosclerosisdevelopment