Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis

One important feature of tumour development is the regulatory role of metabolic plasticity in maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer cells. In recent years, the transition and/or function of metabolic phenotypes between mitochondrial oxidative pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Niu, Nan, Ye, Jinfeng, Hu, Zhangli, Zhang, Junbin, Wang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139088/
https://www.ncbi.nlm.nih.gov/pubmed/37108242
http://dx.doi.org/10.3390/ijms24087076
_version_ 1785032861732044800
author Niu, Nan
Ye, Jinfeng
Hu, Zhangli
Zhang, Junbin
Wang, Yun
author_facet Niu, Nan
Ye, Jinfeng
Hu, Zhangli
Zhang, Junbin
Wang, Yun
author_sort Niu, Nan
collection PubMed
description One important feature of tumour development is the regulatory role of metabolic plasticity in maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer cells. In recent years, the transition and/or function of metabolic phenotypes between mitochondrial oxidative phosphorylation and glycolysis in tumour cells have been extensively studied. In this review, we aimed to elucidate the characteristics of metabolic plasticity (emphasizing their effects, such as immune escape, angiogenesis migration, invasiveness, heterogeneity, adhesion, and phenotypic properties of cancers, among others) on tumour progression, including the initiation and progression phases. Thus, this article provides an overall understanding of the influence of abnormal metabolic remodeling on malignant proliferation and pathophysiological changes in carcinoma.
format Online
Article
Text
id pubmed-10139088
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101390882023-04-28 Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis Niu, Nan Ye, Jinfeng Hu, Zhangli Zhang, Junbin Wang, Yun Int J Mol Sci Review One important feature of tumour development is the regulatory role of metabolic plasticity in maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer cells. In recent years, the transition and/or function of metabolic phenotypes between mitochondrial oxidative phosphorylation and glycolysis in tumour cells have been extensively studied. In this review, we aimed to elucidate the characteristics of metabolic plasticity (emphasizing their effects, such as immune escape, angiogenesis migration, invasiveness, heterogeneity, adhesion, and phenotypic properties of cancers, among others) on tumour progression, including the initiation and progression phases. Thus, this article provides an overall understanding of the influence of abnormal metabolic remodeling on malignant proliferation and pathophysiological changes in carcinoma. MDPI 2023-04-11 /pmc/articles/PMC10139088/ /pubmed/37108242 http://dx.doi.org/10.3390/ijms24087076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Niu, Nan
Ye, Jinfeng
Hu, Zhangli
Zhang, Junbin
Wang, Yun
Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title_full Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title_fullStr Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title_full_unstemmed Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title_short Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis
title_sort regulative roles of metabolic plasticity caused by mitochondrial oxidative phosphorylation and glycolysis on the initiation and progression of tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139088/
https://www.ncbi.nlm.nih.gov/pubmed/37108242
http://dx.doi.org/10.3390/ijms24087076
work_keys_str_mv AT niunan regulativerolesofmetabolicplasticitycausedbymitochondrialoxidativephosphorylationandglycolysisontheinitiationandprogressionoftumorigenesis
AT yejinfeng regulativerolesofmetabolicplasticitycausedbymitochondrialoxidativephosphorylationandglycolysisontheinitiationandprogressionoftumorigenesis
AT huzhangli regulativerolesofmetabolicplasticitycausedbymitochondrialoxidativephosphorylationandglycolysisontheinitiationandprogressionoftumorigenesis
AT zhangjunbin regulativerolesofmetabolicplasticitycausedbymitochondrialoxidativephosphorylationandglycolysisontheinitiationandprogressionoftumorigenesis
AT wangyun regulativerolesofmetabolicplasticitycausedbymitochondrialoxidativephosphorylationandglycolysisontheinitiationandprogressionoftumorigenesis

Ejemplares similares