Defective Mitochondrial Dynamics and Protein Degradation Pathways Underlie Cadmium-Induced Neurotoxicity and Cell Death in Huntington’s Disease Striatal Cells

Exposure to heavy metals, including cadmium (Cd), can induce neurotoxicity and cell death. Cd is abundant in the environment and accumulates in the striatum, the primary brain region selectively affected by Huntington’s disease (HD). We have previously reported that mutant huntingtin protein (mHTT)...

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Detalles Bibliográficos
Autores principales: Kamitsuka, Paul J., Ghanem, Marwan M., Ziar, Rania, McDonald, Sarah E., Thomas, Morgan G., Kwakye, Gunnar F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139096/
https://www.ncbi.nlm.nih.gov/pubmed/37108341
http://dx.doi.org/10.3390/ijms24087178

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