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Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise...

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Autores principales: Kim, Hyunjoong, Jung, Jihye, Park, Sungeon, Joo, Younglan, Lee, Sangbong, Sim, Jeongu, Choi, Jinhyeong, Lee, Hyun, Hwang, Gyujeong, Lee, Seungwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139099/
https://www.ncbi.nlm.nih.gov/pubmed/37108444
http://dx.doi.org/10.3390/ijms24087284
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author Kim, Hyunjoong
Jung, Jihye
Park, Sungeon
Joo, Younglan
Lee, Sangbong
Sim, Jeongu
Choi, Jinhyeong
Lee, Hyun
Hwang, Gyujeong
Lee, Seungwon
author_facet Kim, Hyunjoong
Jung, Jihye
Park, Sungeon
Joo, Younglan
Lee, Sangbong
Sim, Jeongu
Choi, Jinhyeong
Lee, Hyun
Hwang, Gyujeong
Lee, Seungwon
author_sort Kim, Hyunjoong
collection PubMed
description This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise and with and without exercise. For quality assessment, the risk-of-bias assessment tool for nonrandomized studies and the Cochrane risk-of-bias tool were used. A quantitative analysis was performed using the standardized mean difference (SMD) and random-effects model in RevMan 5.4. A total of 94 studies were searched in international electronic databases, and after screening, 10 studies with 376 participants were analyzed. Compared with no exercise, there was a significant increase in the FGF-21 levels from before to after exercise (SMD = 1.05, 95% confidence interval (CI), 0.21 to 1.89). The changes in FGF-21 levels in the exercise group showed a significant difference from the levels in the controls. The results of the random-effects model were as follows: SMD = 1.12; 95% CI, −0.13 to 2.37. While the data on acute exercise were not synthesized in this study, FGF-21 levels generally increased after chronic exercise compared with no exercise.
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spelling pubmed-101390992023-04-28 Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis Kim, Hyunjoong Jung, Jihye Park, Sungeon Joo, Younglan Lee, Sangbong Sim, Jeongu Choi, Jinhyeong Lee, Hyun Hwang, Gyujeong Lee, Seungwon Int J Mol Sci Review This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise and with and without exercise. For quality assessment, the risk-of-bias assessment tool for nonrandomized studies and the Cochrane risk-of-bias tool were used. A quantitative analysis was performed using the standardized mean difference (SMD) and random-effects model in RevMan 5.4. A total of 94 studies were searched in international electronic databases, and after screening, 10 studies with 376 participants were analyzed. Compared with no exercise, there was a significant increase in the FGF-21 levels from before to after exercise (SMD = 1.05, 95% confidence interval (CI), 0.21 to 1.89). The changes in FGF-21 levels in the exercise group showed a significant difference from the levels in the controls. The results of the random-effects model were as follows: SMD = 1.12; 95% CI, −0.13 to 2.37. While the data on acute exercise were not synthesized in this study, FGF-21 levels generally increased after chronic exercise compared with no exercise. MDPI 2023-04-14 /pmc/articles/PMC10139099/ /pubmed/37108444 http://dx.doi.org/10.3390/ijms24087284 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Hyunjoong
Jung, Jihye
Park, Sungeon
Joo, Younglan
Lee, Sangbong
Sim, Jeongu
Choi, Jinhyeong
Lee, Hyun
Hwang, Gyujeong
Lee, Seungwon
Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title_full Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title_fullStr Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title_full_unstemmed Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title_short Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis
title_sort exercise-induced fibroblast growth factor-21: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139099/
https://www.ncbi.nlm.nih.gov/pubmed/37108444
http://dx.doi.org/10.3390/ijms24087284
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