Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Alzheimer’s disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of earl...

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Detalles Bibliográficos
Autores principales: Lopes, Cátia R., Silva, Joana S., Santos, Joana, Rodrigues, Matilde S., Madeira, Daniela, Oliveira, Andreia, Moreira-de-Sá, Ana, Lourenço, Vanessa S., Gonçalves, Francisco Q., Silva, Henrique B., Simões, Ana Patrícia, Rolo, Anabela P., Canas, Paula M., Tomé, Ângelo R., Palmeira, Carlos M., Lopes, João Pedro, Cunha, Rodrigo A., Agostinho, Paula, Ferreira, Samira G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139121/
https://www.ncbi.nlm.nih.gov/pubmed/37108131
http://dx.doi.org/10.3390/ijms24086968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139121/
https://www.ncbi.nlm.nih.gov/pubmed/37108131
http://dx.doi.org/10.3390/ijms24086968

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