Cargando…

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Alzheimer’s disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of earl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopes, Cátia R., Silva, Joana S., Santos, Joana, Rodrigues, Matilde S., Madeira, Daniela, Oliveira, Andreia, Moreira-de-Sá, Ana, Lourenço, Vanessa S., Gonçalves, Francisco Q., Silva, Henrique B., Simões, Ana Patrícia, Rolo, Anabela P., Canas, Paula M., Tomé, Ângelo R., Palmeira, Carlos M., Lopes, João Pedro, Cunha, Rodrigo A., Agostinho, Paula, Ferreira, Samira G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139121/ https://www.ncbi.nlm.nih.gov/pubmed/37108131 http://dx.doi.org/10.3390/ijms24086968

Ejemplares similares

Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A(2A) receptors
por: Madeira, Daniela, et al.
Publicado: (2023)

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas
por: Lopes, Cátia R., et al.
Publicado: (2023)

Adenosine A(2A) Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ(1–42) to Model Early Alzheimer’s Disease
por: Lopes, Cátia R., et al.
Publicado: (2023)

The Role of Yeasts in Human Health: A Review
por: Caetano, Cátia Filipa, et al.
Publicado: (2023)

Adenosine A(2A) receptors control generalization of contextual fear in rats
por: Simões, Ana P., et al.
Publicado: (2023)

Uncovering the Yeast Diversity in the Female Genital Tract: An Exploration of Spatial Distribution and Antifungal Resistance
por: Fernandes, Mariana Zagalo, et al.
Publicado: (2023)

E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer
por: Simões-Correia, Joana, et al.
Publicado: (2012)

Blockade of adenosine A(2A) receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway
por: Simões, Ana Patrícia, et al.
Publicado: (2012)

Lithium-Induced Arginine Vasopressin Resistance (AVP-R): A Case of Chronic Exposure to Lithium
por: Lopes, Andreia, et al.
Publicado: (2023)

Study of Ecological Relationship of Yeast Species with Candida albicans in the Context of Vulvovaginal Infections
por: Caetano, Cátia Filipa, et al.
Publicado: (2023)

Vulvovaginal Candida albicans Clinical Isolates’ Resistance to Phagocytosis In-Vitro
por: Faria-Gonçalves, Paula, et al.
Publicado: (2022)

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy
por: Silva, Rui, et al.
Publicado: (2020)

Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) Gardnerella spp. Biofilms
por: Gaspar, Carlos, et al.
Publicado: (2021)

Favism: A Case Report
por: Diegues, Andreia, et al.
Publicado: (2022)

miR-378a-3p Participates in Metformin’s Mechanism of Action on C2C12 Cells under Hyperglycemia
por: Machado, Ivo F., et al.
Publicado: (2021)

The Role of microRNAs in Mitochondria: Small Players Acting Wide
por: Duarte, Filipe V., et al.
Publicado: (2014)

Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury
por: Machado, Ivo F., et al.
Publicado: (2023)

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients
por: Silva, Rui, et al.
Publicado: (2022)

Astrocytes and Adenosine A(2A) Receptors: Active Players in Alzheimer’s Disease
por: Lopes, Cátia R., et al.
Publicado: (2021)

Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices
por: Sa de Almeida, Joana, et al.
Publicado: (2020)

Bacterial Isolates from Urinary Tract Infection in Dogs and Cats in Portugal, and Their Antibiotic Susceptibility Pattern: A Retrospective Study of 5 Years (2017–2021)
por: Garcês, Andreia, et al.
Publicado: (2022)

Crosstalk Between ATP-P(2X7) and Adenosine A(2A) Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress
por: Dias, Liliana, et al.
Publicado: (2021)

Antimicrobial Activity of Selected Phytochemicals against Escherichia coli and Staphylococcus aureus and Their Biofilms
por: Monte, Joana, et al.
Publicado: (2014)

Severely Asthmatic Horses Residing in a Mediterranean Climate Shed a Significantly Lower Number of Parasite Eggs Compared to Healthy Farm Mates
por: Simões, Joana, et al.
Publicado: (2023)

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents
por: Lemos, Agostinho, et al.
Publicado: (2019)

Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons
por: Baptista, Sofia, et al.
Publicado: (2016)

Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes
por: Teodoro, João S., et al.
Publicado: (2019)

Adenosine A(2A) Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex
por: Kerkhofs, Amber, et al.
Publicado: (2018)

Ultrastructural changes in oocytes during folliculogenesis in domestic mammals
por: Paulini, Fernanda, et al.
Publicado: (2014)

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress
por: Dias, Liliana, et al.
Publicado: (2023)

Predicted Environmental Risk Assessment of Antimicrobials with Increased Consumption in Portugal during the COVID-19 Pandemic; The Groundwork for the Forthcoming Water Quality Survey
por: Almeida, Anabela, et al.
Publicado: (2023)

Beneficial Effect of a Selective Adenosine A(2A) Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
por: Faivre, Emilie, et al.
Publicado: (2018)

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria
por: Teodoro, João S., et al.
Publicado: (2022)

Inhibition of Several Bacterial Species Isolated from Squid and Shrimp Skewers by Different Natural Edible Compounds
por: Pinto de Rezende, Lourenço, et al.
Publicado: (2022)

Homocysteine Is a Risk Factor in Predialysis Patients When Associated with Malnutrition and Inflammation
por: Vieira, Ana de Lurdes Agostinho Cabrita, et al.
Publicado: (2010)

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management
por: Nunes, Andreia, et al.
Publicado: (2020)

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
por: Canas, Paula M., et al.
Publicado: (2018)

PEG35 as a Preconditioning Agent against Hypoxia/Reoxygenation Injury
por: Teixeira da Silva, Rui, et al.
Publicado: (2022)

Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: What has Changed in The Guidelines?
por: Reis, Liliana, et al.
Publicado: (2018)

CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A(2A) Receptor-Mediated Control of Fear Memory and Amygdala Plasticity
por: Simões, Ana Patrícia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ucg7gvqsq6cfbk1d4cp1r5r7k7