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Paraoxonases at the Heart of Neurological Disorders
Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human ch...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139148/ https://www.ncbi.nlm.nih.gov/pubmed/37108044 http://dx.doi.org/10.3390/ijms24086881 |
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author | Khalaf, Fatimah K. Connolly, Jacob Khatib-Shahidi, Bella Albehadili, Abdulsahib Tassavvor, Iman Ranabothu, Meghana Eid, Noha Dube, Prabhatchandra Khouri, Samer J. Malhotra, Deepak Haller, Steven T. Kennedy, David J. |
author_facet | Khalaf, Fatimah K. Connolly, Jacob Khatib-Shahidi, Bella Albehadili, Abdulsahib Tassavvor, Iman Ranabothu, Meghana Eid, Noha Dube, Prabhatchandra Khouri, Samer J. Malhotra, Deepak Haller, Steven T. Kennedy, David J. |
author_sort | Khalaf, Fatimah K. |
collection | PubMed |
description | Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases. |
format | Online Article Text |
id | pubmed-10139148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101391482023-04-28 Paraoxonases at the Heart of Neurological Disorders Khalaf, Fatimah K. Connolly, Jacob Khatib-Shahidi, Bella Albehadili, Abdulsahib Tassavvor, Iman Ranabothu, Meghana Eid, Noha Dube, Prabhatchandra Khouri, Samer J. Malhotra, Deepak Haller, Steven T. Kennedy, David J. Int J Mol Sci Review Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases. MDPI 2023-04-07 /pmc/articles/PMC10139148/ /pubmed/37108044 http://dx.doi.org/10.3390/ijms24086881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khalaf, Fatimah K. Connolly, Jacob Khatib-Shahidi, Bella Albehadili, Abdulsahib Tassavvor, Iman Ranabothu, Meghana Eid, Noha Dube, Prabhatchandra Khouri, Samer J. Malhotra, Deepak Haller, Steven T. Kennedy, David J. Paraoxonases at the Heart of Neurological Disorders |
title | Paraoxonases at the Heart of Neurological Disorders |
title_full | Paraoxonases at the Heart of Neurological Disorders |
title_fullStr | Paraoxonases at the Heart of Neurological Disorders |
title_full_unstemmed | Paraoxonases at the Heart of Neurological Disorders |
title_short | Paraoxonases at the Heart of Neurological Disorders |
title_sort | paraoxonases at the heart of neurological disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139148/ https://www.ncbi.nlm.nih.gov/pubmed/37108044 http://dx.doi.org/10.3390/ijms24086881 |
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