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Paraoxonases at the Heart of Neurological Disorders

Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human ch...

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Autores principales: Khalaf, Fatimah K., Connolly, Jacob, Khatib-Shahidi, Bella, Albehadili, Abdulsahib, Tassavvor, Iman, Ranabothu, Meghana, Eid, Noha, Dube, Prabhatchandra, Khouri, Samer J., Malhotra, Deepak, Haller, Steven T., Kennedy, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139148/
https://www.ncbi.nlm.nih.gov/pubmed/37108044
http://dx.doi.org/10.3390/ijms24086881
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author Khalaf, Fatimah K.
Connolly, Jacob
Khatib-Shahidi, Bella
Albehadili, Abdulsahib
Tassavvor, Iman
Ranabothu, Meghana
Eid, Noha
Dube, Prabhatchandra
Khouri, Samer J.
Malhotra, Deepak
Haller, Steven T.
Kennedy, David J.
author_facet Khalaf, Fatimah K.
Connolly, Jacob
Khatib-Shahidi, Bella
Albehadili, Abdulsahib
Tassavvor, Iman
Ranabothu, Meghana
Eid, Noha
Dube, Prabhatchandra
Khouri, Samer J.
Malhotra, Deepak
Haller, Steven T.
Kennedy, David J.
author_sort Khalaf, Fatimah K.
collection PubMed
description Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases.
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spelling pubmed-101391482023-04-28 Paraoxonases at the Heart of Neurological Disorders Khalaf, Fatimah K. Connolly, Jacob Khatib-Shahidi, Bella Albehadili, Abdulsahib Tassavvor, Iman Ranabothu, Meghana Eid, Noha Dube, Prabhatchandra Khouri, Samer J. Malhotra, Deepak Haller, Steven T. Kennedy, David J. Int J Mol Sci Review Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that share a similar structure and location as a cluster on human chromosome 7. These enzymes exhibit anti-inflammatory and antioxidant properties with well-described roles in preventing cardiovascular disease. Perturbations in PON enzyme levels and their activity have also been linked with the development and progression of many neurological disorders and neurodegenerative diseases. The current review summarizes the available evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders. We present the current findings on the role of PONs in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative and neurological diseases. MDPI 2023-04-07 /pmc/articles/PMC10139148/ /pubmed/37108044 http://dx.doi.org/10.3390/ijms24086881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khalaf, Fatimah K.
Connolly, Jacob
Khatib-Shahidi, Bella
Albehadili, Abdulsahib
Tassavvor, Iman
Ranabothu, Meghana
Eid, Noha
Dube, Prabhatchandra
Khouri, Samer J.
Malhotra, Deepak
Haller, Steven T.
Kennedy, David J.
Paraoxonases at the Heart of Neurological Disorders
title Paraoxonases at the Heart of Neurological Disorders
title_full Paraoxonases at the Heart of Neurological Disorders
title_fullStr Paraoxonases at the Heart of Neurological Disorders
title_full_unstemmed Paraoxonases at the Heart of Neurological Disorders
title_short Paraoxonases at the Heart of Neurological Disorders
title_sort paraoxonases at the heart of neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139148/
https://www.ncbi.nlm.nih.gov/pubmed/37108044
http://dx.doi.org/10.3390/ijms24086881
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