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Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium

The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a...

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Autores principales: Maugeri, Grazia, D’Amico, Agata Grazia, Magrì, Benedetta, Giunta, Salvatore, Musumeci, Giuseppe, Saccone, Salvatore, Federico, Concetta, Scollo, Davide, Longo, Antonio, Avitabile, Teresio, D’Agata, Velia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139171/
https://www.ncbi.nlm.nih.gov/pubmed/37108060
http://dx.doi.org/10.3390/ijms24086895
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author Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Giunta, Salvatore
Musumeci, Giuseppe
Saccone, Salvatore
Federico, Concetta
Scollo, Davide
Longo, Antonio
Avitabile, Teresio
D’Agata, Velia
author_facet Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Giunta, Salvatore
Musumeci, Giuseppe
Saccone, Salvatore
Federico, Concetta
Scollo, Davide
Longo, Antonio
Avitabile, Teresio
D’Agata, Velia
author_sort Maugeri, Grazia
collection PubMed
description The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a previous study, we demonstrated the positive effects of NAP, the active fragment of activity-dependent protein (ADNP), against oxidative stress induced by UV-B radiations. Here, we investigated its role to counteract the inflammatory event triggered by this insult contributing to the disruption of the corneal epithelial barrier. The results indicated that NAP treatment prevents UV-B-induced inflammatory processes by affecting IL-1β cytokine expression and NF-κB activation, as well as maintaining corneal epithelial barrier integrity. These findings may be useful for the future development of an NAP-based therapy for corneal disease.
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spelling pubmed-101391712023-04-28 Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Giunta, Salvatore Musumeci, Giuseppe Saccone, Salvatore Federico, Concetta Scollo, Davide Longo, Antonio Avitabile, Teresio D’Agata, Velia Int J Mol Sci Article The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a previous study, we demonstrated the positive effects of NAP, the active fragment of activity-dependent protein (ADNP), against oxidative stress induced by UV-B radiations. Here, we investigated its role to counteract the inflammatory event triggered by this insult contributing to the disruption of the corneal epithelial barrier. The results indicated that NAP treatment prevents UV-B-induced inflammatory processes by affecting IL-1β cytokine expression and NF-κB activation, as well as maintaining corneal epithelial barrier integrity. These findings may be useful for the future development of an NAP-based therapy for corneal disease. MDPI 2023-04-07 /pmc/articles/PMC10139171/ /pubmed/37108060 http://dx.doi.org/10.3390/ijms24086895 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maugeri, Grazia
D’Amico, Agata Grazia
Magrì, Benedetta
Giunta, Salvatore
Musumeci, Giuseppe
Saccone, Salvatore
Federico, Concetta
Scollo, Davide
Longo, Antonio
Avitabile, Teresio
D’Agata, Velia
Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title_full Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title_fullStr Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title_full_unstemmed Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title_short Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
title_sort regulation of uv-b-induced inflammatory mediators by activity-dependent neuroprotective protein (adnp)-derived peptide (nap) in corneal epithelium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139171/
https://www.ncbi.nlm.nih.gov/pubmed/37108060
http://dx.doi.org/10.3390/ijms24086895
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