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Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139171/ https://www.ncbi.nlm.nih.gov/pubmed/37108060 http://dx.doi.org/10.3390/ijms24086895 |
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author | Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Giunta, Salvatore Musumeci, Giuseppe Saccone, Salvatore Federico, Concetta Scollo, Davide Longo, Antonio Avitabile, Teresio D’Agata, Velia |
author_facet | Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Giunta, Salvatore Musumeci, Giuseppe Saccone, Salvatore Federico, Concetta Scollo, Davide Longo, Antonio Avitabile, Teresio D’Agata, Velia |
author_sort | Maugeri, Grazia |
collection | PubMed |
description | The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a previous study, we demonstrated the positive effects of NAP, the active fragment of activity-dependent protein (ADNP), against oxidative stress induced by UV-B radiations. Here, we investigated its role to counteract the inflammatory event triggered by this insult contributing to the disruption of the corneal epithelial barrier. The results indicated that NAP treatment prevents UV-B-induced inflammatory processes by affecting IL-1β cytokine expression and NF-κB activation, as well as maintaining corneal epithelial barrier integrity. These findings may be useful for the future development of an NAP-based therapy for corneal disease. |
format | Online Article Text |
id | pubmed-10139171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101391712023-04-28 Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Giunta, Salvatore Musumeci, Giuseppe Saccone, Salvatore Federico, Concetta Scollo, Davide Longo, Antonio Avitabile, Teresio D’Agata, Velia Int J Mol Sci Article The corneal epithelium, representing the outermost layer of the cornea, acts as a barrier to protect the eye against external insults such as ultraviolet B (UV-B) radiations. The inflammatory response induced by these adverse events can alter the corneal structure, leading to visual impairment. In a previous study, we demonstrated the positive effects of NAP, the active fragment of activity-dependent protein (ADNP), against oxidative stress induced by UV-B radiations. Here, we investigated its role to counteract the inflammatory event triggered by this insult contributing to the disruption of the corneal epithelial barrier. The results indicated that NAP treatment prevents UV-B-induced inflammatory processes by affecting IL-1β cytokine expression and NF-κB activation, as well as maintaining corneal epithelial barrier integrity. These findings may be useful for the future development of an NAP-based therapy for corneal disease. MDPI 2023-04-07 /pmc/articles/PMC10139171/ /pubmed/37108060 http://dx.doi.org/10.3390/ijms24086895 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maugeri, Grazia D’Amico, Agata Grazia Magrì, Benedetta Giunta, Salvatore Musumeci, Giuseppe Saccone, Salvatore Federico, Concetta Scollo, Davide Longo, Antonio Avitabile, Teresio D’Agata, Velia Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title | Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title_full | Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title_fullStr | Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title_full_unstemmed | Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title_short | Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium |
title_sort | regulation of uv-b-induced inflammatory mediators by activity-dependent neuroprotective protein (adnp)-derived peptide (nap) in corneal epithelium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139171/ https://www.ncbi.nlm.nih.gov/pubmed/37108060 http://dx.doi.org/10.3390/ijms24086895 |
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