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Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica
Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139191/ https://www.ncbi.nlm.nih.gov/pubmed/37108178 http://dx.doi.org/10.3390/ijms24087016 |
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author | Martynova, Ekaterina Stott-Marshall, Robert J. Shakirova, Venera Saubanova, Albina Bulatova, Asiya Davidyuk, Yuriy N. Kabwe, Emmanuel Markelova, Maria Khaertynova, Ilseyar Foster, Toshana L. Khaiboullina, Svetlana |
author_facet | Martynova, Ekaterina Stott-Marshall, Robert J. Shakirova, Venera Saubanova, Albina Bulatova, Asiya Davidyuk, Yuriy N. Kabwe, Emmanuel Markelova, Maria Khaertynova, Ilseyar Foster, Toshana L. Khaiboullina, Svetlana |
author_sort | Martynova, Ekaterina |
collection | PubMed |
description | Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of clinical and laboratory data revealed that NE was milder in children than in adults. A variation in serum cytokine activation could explain the differences in clinical presentation. Cytokines associated with activation of Th1 lymphocytes were prominent in adults, while they were obscured in sera from pediatric NE patients. In addition, a prolonged activation of kidney injury markers was found in adults with NE, whilst only a short-lasting activation of these markers was observed in children with NE. These findings support previous observations of age differences in NE severity, which should be considered when diagnosing the disease in children. |
format | Online Article Text |
id | pubmed-10139191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101391912023-04-28 Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica Martynova, Ekaterina Stott-Marshall, Robert J. Shakirova, Venera Saubanova, Albina Bulatova, Asiya Davidyuk, Yuriy N. Kabwe, Emmanuel Markelova, Maria Khaertynova, Ilseyar Foster, Toshana L. Khaiboullina, Svetlana Int J Mol Sci Article Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of clinical and laboratory data revealed that NE was milder in children than in adults. A variation in serum cytokine activation could explain the differences in clinical presentation. Cytokines associated with activation of Th1 lymphocytes were prominent in adults, while they were obscured in sera from pediatric NE patients. In addition, a prolonged activation of kidney injury markers was found in adults with NE, whilst only a short-lasting activation of these markers was observed in children with NE. These findings support previous observations of age differences in NE severity, which should be considered when diagnosing the disease in children. MDPI 2023-04-10 /pmc/articles/PMC10139191/ /pubmed/37108178 http://dx.doi.org/10.3390/ijms24087016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martynova, Ekaterina Stott-Marshall, Robert J. Shakirova, Venera Saubanova, Albina Bulatova, Asiya Davidyuk, Yuriy N. Kabwe, Emmanuel Markelova, Maria Khaertynova, Ilseyar Foster, Toshana L. Khaiboullina, Svetlana Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title_full | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title_fullStr | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title_full_unstemmed | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title_short | Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica |
title_sort | differential cytokine responses and the clinical severity of adult and pediatric nephropathia epidemica |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139191/ https://www.ncbi.nlm.nih.gov/pubmed/37108178 http://dx.doi.org/10.3390/ijms24087016 |
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