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An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis

In recent years, the importance of epigenetic markers in the carcinogenesis of different malignant neoplasms has been demonstrated, also demonstrating their utility for understanding metastatic spread and tumor progression in cancer patients. Among the different biomarkers, microRNAs represent a set...

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Autores principales: Pekarek, Leonel, Torres-Carranza, Diego, Fraile-Martinez, Oscar, García-Montero, Cielo, Pekarek, Tatiana, Saez, Miguel A., Rueda-Correa, Francisco, Pimentel-Martinez, Carolina, Guijarro, Luis G., Diaz-Pedrero, Raul, Alvarez-Mon, Melchor, Ortega, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139430/
https://www.ncbi.nlm.nih.gov/pubmed/37108432
http://dx.doi.org/10.3390/ijms24087268
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author Pekarek, Leonel
Torres-Carranza, Diego
Fraile-Martinez, Oscar
García-Montero, Cielo
Pekarek, Tatiana
Saez, Miguel A.
Rueda-Correa, Francisco
Pimentel-Martinez, Carolina
Guijarro, Luis G.
Diaz-Pedrero, Raul
Alvarez-Mon, Melchor
Ortega, Miguel A.
author_facet Pekarek, Leonel
Torres-Carranza, Diego
Fraile-Martinez, Oscar
García-Montero, Cielo
Pekarek, Tatiana
Saez, Miguel A.
Rueda-Correa, Francisco
Pimentel-Martinez, Carolina
Guijarro, Luis G.
Diaz-Pedrero, Raul
Alvarez-Mon, Melchor
Ortega, Miguel A.
author_sort Pekarek, Leonel
collection PubMed
description In recent years, the importance of epigenetic markers in the carcinogenesis of different malignant neoplasms has been demonstrated, also demonstrating their utility for understanding metastatic spread and tumor progression in cancer patients. Among the different biomarkers, microRNAs represent a set of non-coding RNAs that regulate gene expression, having been involved in a wide variety of neoplasia acting in different oncogenic pathways. Both the overexpression and downregulation of microRNAs represent a complex interaction with various genes whose ultimate consequence is increased cell proliferation, tumor invasion and interaction with various driver markers. It should be noted that in current clinical practice, even though the combination of different microRNAs has been shown to be useful by different authors at diagnostic and prognostic levels, there are no diagnostic kits that can be used for the initial approach or to assess recurrences of oncological diseases. Previous works have cited microRNAs as having a critical role in several carcinogenic mechanisms, ranging from cell cycle alterations to angiogenesis and mechanisms of distant metastatic dissemination. Indeed, the overexpression or downregulation of specific microRNAs seem to be tightly involved in the modulation of various components related to these processes. For instance, cyclins and cyclin-dependent kinases, transcription factors, signaling molecules and angiogenic/antiangiogenic products, among others, have been recognized as specific targets of microRNAs in different types of cancer. Therefore, the purpose of this article is to describe the main implications of different microRNAs in cell cycle alterations, metastasis and angiogenesis, trying to summarize their involvement in carcinogenesis.
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spelling pubmed-101394302023-04-28 An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis Pekarek, Leonel Torres-Carranza, Diego Fraile-Martinez, Oscar García-Montero, Cielo Pekarek, Tatiana Saez, Miguel A. Rueda-Correa, Francisco Pimentel-Martinez, Carolina Guijarro, Luis G. Diaz-Pedrero, Raul Alvarez-Mon, Melchor Ortega, Miguel A. Int J Mol Sci Review In recent years, the importance of epigenetic markers in the carcinogenesis of different malignant neoplasms has been demonstrated, also demonstrating their utility for understanding metastatic spread and tumor progression in cancer patients. Among the different biomarkers, microRNAs represent a set of non-coding RNAs that regulate gene expression, having been involved in a wide variety of neoplasia acting in different oncogenic pathways. Both the overexpression and downregulation of microRNAs represent a complex interaction with various genes whose ultimate consequence is increased cell proliferation, tumor invasion and interaction with various driver markers. It should be noted that in current clinical practice, even though the combination of different microRNAs has been shown to be useful by different authors at diagnostic and prognostic levels, there are no diagnostic kits that can be used for the initial approach or to assess recurrences of oncological diseases. Previous works have cited microRNAs as having a critical role in several carcinogenic mechanisms, ranging from cell cycle alterations to angiogenesis and mechanisms of distant metastatic dissemination. Indeed, the overexpression or downregulation of specific microRNAs seem to be tightly involved in the modulation of various components related to these processes. For instance, cyclins and cyclin-dependent kinases, transcription factors, signaling molecules and angiogenic/antiangiogenic products, among others, have been recognized as specific targets of microRNAs in different types of cancer. Therefore, the purpose of this article is to describe the main implications of different microRNAs in cell cycle alterations, metastasis and angiogenesis, trying to summarize their involvement in carcinogenesis. MDPI 2023-04-14 /pmc/articles/PMC10139430/ /pubmed/37108432 http://dx.doi.org/10.3390/ijms24087268 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pekarek, Leonel
Torres-Carranza, Diego
Fraile-Martinez, Oscar
García-Montero, Cielo
Pekarek, Tatiana
Saez, Miguel A.
Rueda-Correa, Francisco
Pimentel-Martinez, Carolina
Guijarro, Luis G.
Diaz-Pedrero, Raul
Alvarez-Mon, Melchor
Ortega, Miguel A.
An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title_full An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title_fullStr An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title_full_unstemmed An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title_short An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis
title_sort overview of the role of micrornas on carcinogenesis: a focus on cell cycle, angiogenesis and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139430/
https://www.ncbi.nlm.nih.gov/pubmed/37108432
http://dx.doi.org/10.3390/ijms24087268
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