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Arterial hypertension in kidney transplantation: huge importance, but few answers

Arterial hypertension (AH) after renal transplantation (RTX) is correlated with worse cardiovascular and renal outcomes, with loss of renal function, decreased graft survival and higher mortality. RTX recipients have discrepant blood pressure (BP) values when measured in the office or by systematic...

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Autores principales: Rebelo, Rafael Naufel de Sá, Rodrigues, Cibele Isaac Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139712/
https://www.ncbi.nlm.nih.gov/pubmed/36269977
http://dx.doi.org/10.1590/2175-8239-JBN-2022-0109en
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author Rebelo, Rafael Naufel de Sá
Rodrigues, Cibele Isaac Saad
author_facet Rebelo, Rafael Naufel de Sá
Rodrigues, Cibele Isaac Saad
author_sort Rebelo, Rafael Naufel de Sá
collection PubMed
description Arterial hypertension (AH) after renal transplantation (RTX) is correlated with worse cardiovascular and renal outcomes, with loss of renal function, decreased graft survival and higher mortality. RTX recipients have discrepant blood pressure (BP) values when measured in the office or by systematic methodologies, such as Ambulatory Blood Pressure Monitoring (ABPM), with significant prevalence of no nocturnal dipping or nocturnal hypertension, white coat hypertension and masked hypertension. The aim of the present study was to review the issue of hypertension in RTX, addressing its multifactorial pathophysiology and demonstrating the importance of ABPM as a tool for monitoring BP in these patients. Treatment is based on lifestyle changes and antihypertensive drugs, with calcium channel blockers considered first-line treatment. The best blood pressure target and treatment with more favorable outcomes in RTX are yet to be determined, through well-conducted scientific studies, that is, in terms of AH in RTX, we currently have more questions to answer than answers to give.
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spelling pubmed-101397122023-04-28 Arterial hypertension in kidney transplantation: huge importance, but few answers Rebelo, Rafael Naufel de Sá Rodrigues, Cibele Isaac Saad J Bras Nefrol Review Article Arterial hypertension (AH) after renal transplantation (RTX) is correlated with worse cardiovascular and renal outcomes, with loss of renal function, decreased graft survival and higher mortality. RTX recipients have discrepant blood pressure (BP) values when measured in the office or by systematic methodologies, such as Ambulatory Blood Pressure Monitoring (ABPM), with significant prevalence of no nocturnal dipping or nocturnal hypertension, white coat hypertension and masked hypertension. The aim of the present study was to review the issue of hypertension in RTX, addressing its multifactorial pathophysiology and demonstrating the importance of ABPM as a tool for monitoring BP in these patients. Treatment is based on lifestyle changes and antihypertensive drugs, with calcium channel blockers considered first-line treatment. The best blood pressure target and treatment with more favorable outcomes in RTX are yet to be determined, through well-conducted scientific studies, that is, in terms of AH in RTX, we currently have more questions to answer than answers to give. Sociedade Brasileira de Nefrologia 2022-10-21 2023 /pmc/articles/PMC10139712/ /pubmed/36269977 http://dx.doi.org/10.1590/2175-8239-JBN-2022-0109en Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rebelo, Rafael Naufel de Sá
Rodrigues, Cibele Isaac Saad
Arterial hypertension in kidney transplantation: huge importance, but few answers
title Arterial hypertension in kidney transplantation: huge importance, but few answers
title_full Arterial hypertension in kidney transplantation: huge importance, but few answers
title_fullStr Arterial hypertension in kidney transplantation: huge importance, but few answers
title_full_unstemmed Arterial hypertension in kidney transplantation: huge importance, but few answers
title_short Arterial hypertension in kidney transplantation: huge importance, but few answers
title_sort arterial hypertension in kidney transplantation: huge importance, but few answers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139712/
https://www.ncbi.nlm.nih.gov/pubmed/36269977
http://dx.doi.org/10.1590/2175-8239-JBN-2022-0109en
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