Nucleation and dissolution mechanism underlying amyotrophic lateral sclerosis/frontotemporal lobar dementia-linked fused in sarcoma condensates

Fused in sarcoma (FUS) is a nuclear RNA-binding protein. Mutations in FUS lead to the mislocalization of FUS from the nucleus to the cytosol and formation of pathogenic aggregates in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), ye...

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Detalles Bibliográficos
Autores principales: Djaja, Nathalie A., Chang, Matthew T., Beinart, Freya R., Morris, Vivian M., Ganser, Laura R., Myong, Sua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139993/
https://www.ncbi.nlm.nih.gov/pubmed/37123224
http://dx.doi.org/10.1016/j.isci.2023.106537

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