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Iruplinalkib (WX‑0593), a novel ALK/ROS1 inhibitor, overcomes crizotinib resistance in preclinical models for non-small cell lung cancer

Despite remarkable initial responses of anaplastic lymphoma kinase (ALK) inhibitors in ALK-positive non-small cell lung cancer (NSCLC) patients, cancers eventually develop resistance within one to two years. This study aimed to compare the properties of iruplinalkib (WX‑0593) with other ALK inhibito...

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Detalles Bibliográficos
Autores principales:	Yang, Yingying, Zheng, Qingmei, Wang, Xinmei, Zhao, Shuyong, Huang, Wenshu, Jia, Linchao, Ma, Cuicui, Liu, Shicong, Zhang, Yongpeng, Xin, Qianqian, Sun, Yan, Zheng, Shansong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140010/ https://www.ncbi.nlm.nih.gov/pubmed/37036582 http://dx.doi.org/10.1007/s10637-023-01350-x

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