Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune response, but little is known about complement evasion particularly at the early stage of infection. Here we show that ISG65 of the human-infective parasite Trypanosoma brucei gambiense is a receptor for human com...

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Detalles Bibliográficos
Autores principales: Sülzen, Hagen, Began, Jakub, Dhillon, Arun, Kereïche, Sami, Pompach, Petr, Votrubova, Jitka, Zahedifard, Farnaz, Šubrtova, Adriana, Šafner, Marie, Hubalek, Martin, Thompson, Maaike, Zoltner, Martin, Zoll, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140031/
https://www.ncbi.nlm.nih.gov/pubmed/37105991
http://dx.doi.org/10.1038/s41467-023-37988-7

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