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Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2’s nuclease activity

Telomerase-independent cancer proliferation via the alternative lengthening of telomeres (ALT) relies upon two distinct, largely uncharacterized, break-induced-replication (BIR) processes. How cancer cells initiate and regulate these terminal repair mechanisms is unknown. Here, we establish that the...

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Detalles Bibliográficos
Autores principales:	Broderick, Ronan, Cherdyntseva, Veronica, Nieminuszczy, Jadwiga, Dragona, Eleni, Kyriakaki, Maria, Evmorfopoulou, Theodora, Gagos, Sarantis, Niedzwiedz, Wojciech
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140042/ https://www.ncbi.nlm.nih.gov/pubmed/37105990 http://dx.doi.org/10.1038/s41467-023-38029-z

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