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Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies

STUDY DESIGN: Systematic review. BACKGROUND: Although degenerative cervical myelopathy (DCM) is the most prevalent spinal cord condition worldwide, the pathophysiology remains poorly understood. Our objective was to evaluate existing histological findings of DCM on cadaveric human spinal cord tissue...

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Autores principales: Dohle, Esmee, Beardall, Sophie, Chang, Aina, Mena, Karla P. Corral, Jovanović, Luka, Nath, Upamanyu, Lee, Keng Siang, Smith, Alexandria H., Thirunavukarasu, Arun J., Touzet, Alvaro Yanez, Norton, Emma Jane, Mowforth, Oliver D., Kotter, Mark R. N., Davies, Benjamin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140111/
https://www.ncbi.nlm.nih.gov/pubmed/36820887
http://dx.doi.org/10.1007/s00701-023-05526-5
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author Dohle, Esmee
Beardall, Sophie
Chang, Aina
Mena, Karla P. Corral
Jovanović, Luka
Nath, Upamanyu
Lee, Keng Siang
Smith, Alexandria H.
Thirunavukarasu, Arun J.
Touzet, Alvaro Yanez
Norton, Emma Jane
Mowforth, Oliver D.
Kotter, Mark R. N.
Davies, Benjamin M.
author_facet Dohle, Esmee
Beardall, Sophie
Chang, Aina
Mena, Karla P. Corral
Jovanović, Luka
Nath, Upamanyu
Lee, Keng Siang
Smith, Alexandria H.
Thirunavukarasu, Arun J.
Touzet, Alvaro Yanez
Norton, Emma Jane
Mowforth, Oliver D.
Kotter, Mark R. N.
Davies, Benjamin M.
author_sort Dohle, Esmee
collection PubMed
description STUDY DESIGN: Systematic review. BACKGROUND: Although degenerative cervical myelopathy (DCM) is the most prevalent spinal cord condition worldwide, the pathophysiology remains poorly understood. Our objective was to evaluate existing histological findings of DCM on cadaveric human spinal cord tissue and explore their consistency with animal models. METHODS: MEDLINE and Embase were systematically searched (CRD42021281462) for primary research reporting on histological findings of DCM in human cadaveric spinal cord tissue. Data was extracted using a piloted proforma. Risk of bias was assessed using Joanna Briggs Institute critical appraisal tools. Findings were compared to a systematic review of animal models (Ahkter et al. 2020 Front Neurosci 14). RESULTS: The search yielded 4127 unique records. After abstract and full-text screening, 19 were included in the final analysis, reporting on 150 autopsies (71% male) with an average age at death of 67.3 years. All findings were based on haematoxylin and eosin (H&E) staining. The most commonly reported grey matter findings included neuronal loss and cavity formation. The most commonly reported white matter finding was demyelination. Axon loss, gliosis, necrosis and Schwann cell proliferation were also reported. Findings were consistent amongst cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament. Cavitation was notably more prevalent in human autopsies compared to animal models. CONCLUSION: Few human spinal cord tissue studies have been performed. Neuronal loss, demyelination and cavitation were common findings. Investigating the biological basis of DCM is a critical research priority. Human spinal cord specimen may be an underutilised but complimentary approach. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00701-023-05526-5.
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spelling pubmed-101401112023-04-29 Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies Dohle, Esmee Beardall, Sophie Chang, Aina Mena, Karla P. Corral Jovanović, Luka Nath, Upamanyu Lee, Keng Siang Smith, Alexandria H. Thirunavukarasu, Arun J. Touzet, Alvaro Yanez Norton, Emma Jane Mowforth, Oliver D. Kotter, Mark R. N. Davies, Benjamin M. Acta Neurochir (Wien) Original Article - Spine degenerative STUDY DESIGN: Systematic review. BACKGROUND: Although degenerative cervical myelopathy (DCM) is the most prevalent spinal cord condition worldwide, the pathophysiology remains poorly understood. Our objective was to evaluate existing histological findings of DCM on cadaveric human spinal cord tissue and explore their consistency with animal models. METHODS: MEDLINE and Embase were systematically searched (CRD42021281462) for primary research reporting on histological findings of DCM in human cadaveric spinal cord tissue. Data was extracted using a piloted proforma. Risk of bias was assessed using Joanna Briggs Institute critical appraisal tools. Findings were compared to a systematic review of animal models (Ahkter et al. 2020 Front Neurosci 14). RESULTS: The search yielded 4127 unique records. After abstract and full-text screening, 19 were included in the final analysis, reporting on 150 autopsies (71% male) with an average age at death of 67.3 years. All findings were based on haematoxylin and eosin (H&E) staining. The most commonly reported grey matter findings included neuronal loss and cavity formation. The most commonly reported white matter finding was demyelination. Axon loss, gliosis, necrosis and Schwann cell proliferation were also reported. Findings were consistent amongst cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament. Cavitation was notably more prevalent in human autopsies compared to animal models. CONCLUSION: Few human spinal cord tissue studies have been performed. Neuronal loss, demyelination and cavitation were common findings. Investigating the biological basis of DCM is a critical research priority. Human spinal cord specimen may be an underutilised but complimentary approach. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00701-023-05526-5. Springer Vienna 2023-02-23 2023 /pmc/articles/PMC10140111/ /pubmed/36820887 http://dx.doi.org/10.1007/s00701-023-05526-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article - Spine degenerative
Dohle, Esmee
Beardall, Sophie
Chang, Aina
Mena, Karla P. Corral
Jovanović, Luka
Nath, Upamanyu
Lee, Keng Siang
Smith, Alexandria H.
Thirunavukarasu, Arun J.
Touzet, Alvaro Yanez
Norton, Emma Jane
Mowforth, Oliver D.
Kotter, Mark R. N.
Davies, Benjamin M.
Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title_full Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title_fullStr Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title_full_unstemmed Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title_short Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
title_sort human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: findings from a systematic review of human autopsies
topic Original Article - Spine degenerative
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140111/
https://www.ncbi.nlm.nih.gov/pubmed/36820887
http://dx.doi.org/10.1007/s00701-023-05526-5
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