Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides

Phytosphingosine (PHS) is a sphingolipid component present mainly in epithelial tissues, including the epidermis and those lining the digestive tract. DEGS2 is a bifunctional enzyme that produces ceramides (CERs) containing PHS (PHS-CERs) via hydroxylation and sphingosine-CERs via desaturation, usin...

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Detalles Bibliográficos
Autores principales: Ota, Ai, Morita, Hiroya, Naganuma, Tatsuro, Miyamoto, Masatoshi, Jojima, Keisuke, Nojiri, Koki, Matsuda, Junko, Kihara, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140171/
https://www.ncbi.nlm.nih.gov/pubmed/36907437
http://dx.doi.org/10.1016/j.jbc.2023.104603

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