Cargando…

Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma

BACKGROUND: Understanding the spatial heterogeneity of the tumor microenvironment (TME) in pancreatic cancer (PC) remains challenging. METHODS: In this study, we performed spatial transcriptomics (ST) to investigate the gene expression features across one normal pancreatic tissue, PC tissue, adjacen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Zhangyong, Pan, Bing, Wang, Fangfei, Lyu, Shaocheng, Zhai, Jialei, Hu, Xiumei, Liu, Zhe, Li, Lixin, Lang, Ren, He, Qiang, Zhao, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140349/ https://www.ncbi.nlm.nih.gov/pubmed/37124494 http://dx.doi.org/10.3389/fonc.2023.1112576

Ejemplares similares

Dipeptidyl peptidase like 6 promoter methylation is a potential prognostic biomarker for pancreatic ductal adenocarcinoma
por: Zhao, Xin, et al.
Publicado: (2020)

Establishment of rat allogenic vein replacement model and pathological characteristics of the replaced vessels
por: Ren, Zhangyong, et al.
Publicado: (2022)

Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma
por: Zhao, Xin, et al.
Publicado: (2021)

Prognostic impact of lymph node parameters in distal cholangiocarcinoma after pancreaticoduodenectomy
por: Lyu, Shaocheng, et al.
Publicado: (2020)

Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer
por: Peng, H. H., et al.
Publicado: (2021)

FGG-NUFFT-Based Method for Near-Field 3-D Imaging Using Millimeter Waves
por: Kan, Yingzhi, et al.
Publicado: (2016)

Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients
por: Kupcinskiene, Kristina, et al.
Publicado: (2016)

FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition
por: Zhang, Xiang, et al.
Publicado: (2019)

Cortical atrophy and hypofibrinogenemia due to FGG and TBCD mutations in a single family: a case report
por: Stephen, Joshi, et al.
Publicado: (2018)

Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma
por: Zhao, Xin, et al.
Publicado: (2020)

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma
por: Awaji, Mohammad, et al.
Publicado: (2019)

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
por: Zhang, Tianyi, et al.
Publicado: (2022)

Effect of CRP and Kinetics of CRP in Prognosis of Nasopharyngeal Carcinoma
por: Chen, Ruiwan, et al.
Publicado: (2019)

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
por: Vaish, Utpreksha, et al.
Publicado: (2021)

Multiphasic Heterogeneity of Fibroblasts in the Microenvironment of Pancreatic Ductal Adenocarcinoma: Dissection and the Sum of the Dynamics
por: Ijichi, Hideaki
Publicado: (2022)

Horizontal continuous and apical stretching sutures does not reduce FGG shrinkage: a split-mouth randomized controlled clinical trial
por: Shammas, Amir, et al.
Publicado: (2020)

Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG
por: Duan, Shijie, et al.
Publicado: (2018)

Polymorphism rs2066865 in the Fibrinogen Gamma Chain (FGG) Gene Increases Plasma Fibrinogen Concentration and Is Associated with an Increased Microvascular Thrombosis Rate
por: Drizlionoka, Karina, et al.
Publicado: (2019)

PB2642: EVALUATION OF INNOVATIVE LABORATORY TESTS TO PREDICT A THROMBOTIC PHENOTYPE IN A FAMILY WITH DYSFIBRINOGENEMIA AND A NOVEL FGG MUTATION.
por: Monard, Amaury, et al.
Publicado: (2023)

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinoma
por: Neuzillet, Cindy, et al.
Publicado: (2019)

Cancer-associated fibroblast heterogeneity is associated with organ-specific metastasis in pancreatic ductal adenocarcinoma
por: Pan, Xingyi, et al.
Publicado: (2021)

The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
por: Cheng, Rui, et al.
Publicado: (2023)

The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
por: Wang, Di, et al.
Publicado: (2023)

Genetic Variants in the FGB and FGG Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype
por: Simurda, Tomas, et al.
Publicado: (2020)

Prognostic value of perioperative serum low-density lipoprotein cholesterol level for postoperative prognosis of pancreatic cancer: a retrospective study
por: Wang, Hanxuan, et al.
Publicado: (2023)

Combining CRP and CA19-9 in a novel prognostic score in pancreatic ductal adenocarcinoma
por: Nurmi, Anna M., et al.
Publicado: (2021)

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
por: Liang, Chao, et al.
Publicado: (2019)

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family
por: Guipponi, Michel, et al.
Publicado: (2021)

Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
por: Aldous, Noura, et al.
Publicado: (2023)

Heterogeneity of Islet Cells during Embryogenesis and Differentiation
por: Sasaki, Shugo, et al.
Publicado: (2023)

Seed-Induced Heterogeneous Cross-Seeding Self-Assembly of Human and Rat Islet Polypeptides
por: Hu, Rundong, et al.
Publicado: (2017)

Author Correction: HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
por: Liang, Chao, et al.
Publicado: (2020)

Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy
por: Liu, Qun, et al.
Publicado: (2021)

Islet Transplantation & β-Cell Replacement Therapies for Diabetes
por: Berney, Thierry, et al.
Publicado: (2011)

A replacement for islet equivalents with improved reliability and validity
por: Huang, Han-Hung, et al.
Publicado: (2012)

The promise of stem cell-derived islet replacement therapy
por: Melton, Douglas
Publicado: (2021)

Patch‐seq shows the heterogeneity of pancreatic islet cells
por: Asahara, Shun‐ichiro
Publicado: (2021)

Pancreatic ductal cells may have a negative effect on human islet transplantation
por: Marín-Cañas, Sandra, et al.
Publicado: (2019)

Recruited fibroblasts reconstitute the peri-islet membrane: a longitudinal imaging study of human islet grafting and revascularisation
por: Nilsson, Julia, et al.
Publicado: (2019)

Specific Subtypes of Carcinoma-Associated Fibroblasts Are Correlated with Worse Survival in Resectable Pancreatic Ductal Adenocarcinoma
por: Knipper, Karl, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vk41sng4vc64fotrnkh22qnij2