Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies

PURPOSE: CAR-T cell therapy has proven to be a disruptive treatment in the hematology field, however, less than 50% of patients maintain long-term response and early predictors of outcome are still inconsistently defined. Here, we aimed to optimize the detection of CD19 CAR-T cells in blood and to i...

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Detalles Bibliográficos
Autores principales: García-Calderón, Clara Beatriz, Sierro-Martínez, Belén, García-Guerrero, Estefanía, Sanoja-Flores, Luzalba, Muñoz-García, Raquel, Ruiz-Maldonado, Victoria, Jimenez-Leon, María Reyes, Delgado-Serrano, Javier, Molinos-Quintana, Águeda, Guijarro-Albaladejo, Beatriz, Carrasco-Brocal, Inmaculada, Lucena, José-Manuel, García-Lozano, José-Raúl, Blázquez-Goñi, Cristina, Reguera-Ortega, Juan Luis, González-Escribano, María-Francisca, Reinoso-Segura, Marta, Briones, Javier, Pérez-Simón, José Antonio, Caballero-Velázquez, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140355/
https://www.ncbi.nlm.nih.gov/pubmed/37122702
http://dx.doi.org/10.3389/fimmu.2023.1152498

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