Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages

BACKGROUND: Melanoma has the highest mortality rate among all the types of skin cancer. In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the invasiveness of tumor cells and a poor prognosis. Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the in...

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Detalles Bibliográficos
Autores principales: Jeong, Chanmi, Kim, Jeongdong, Han, Ik-Hwan, Kim, Soyoung, Choi, Ilseob, Kim, Hongsung, Jeong, Jin-Hyun, Bae, Hyunsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140360/
https://www.ncbi.nlm.nih.gov/pubmed/37122692
http://dx.doi.org/10.3389/fimmu.2023.1178776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140360/
https://www.ncbi.nlm.nih.gov/pubmed/37122692
http://dx.doi.org/10.3389/fimmu.2023.1178776

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